Question | Discussion | References | CME Credit

Case 6: Methicillin-Resistant Staphylococcus aureus (MRSA) Skin and Soft Tissue Infections

You answered:

C Ciprofloxacin (Cipro) is one of the preferred oral regimens.

This answer is incorrect. Community-acquired isolates of MRSA also frequently show resistance to fluoroquinolones, such as ciprofloxacin, and thus ciprofloxacin is not considered a preferred regimen. Preferred antimicrobials for community-acquired skin and soft tissue MRSA infections include trimethoprim-sulfamethoxazole (Bactrim, Septra), doxycycline, minocycline, clindamycin, and linezolid (Zyvox).

A Resistance to methicillin and cephalexin results from production of an altered penicillin-binding protein by S. aureus that has reduced affinity for binding to beta-lactam antibiotics.
B More than 30% of the isolates from skin and soft tissue infections have shown resistance to trimethoprim-sulfamethoxazole (Bactrim, Septra).
D In a patient allergic to trimethoprim-sulfamethoxazole, azithromycin (Zithromax) is considered the preferred alternative.

[Back to Case 6 Question | Go to Correct Answer]