Case 1: Drug Interactions with Antiretroviral Medications

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Initial Evaluation
Dermatologic Manifestations
Oral Manifestations
OIs: Prophylaxis
OIs: Treatment
Antiretroviral Rx
Antiretroviral Rx: Resistance
Antiretroviral Rx: Adverse Effects
Drug-Drug Interactions
Postexposure Prophylaxis
Perinatal Transmission
Special Populations
Prevention for Positives
Challenging Unknowns
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Question | Discussion | References | CME Credit

You answered:

	Ritonavir significantly decreases the half-life of indinavir.

This answer is incorrect. Both indinavir and ritonavir are metabolized by the CYP3A4 isozyme. Because ritonavir is a potent inhibitor of this enzyme, it decreases the metabolism of indinavir, thus extending the half-life of indinavir.

Choose another answer:

	Didanosine enteric-coated capsules (Videx EC) will markedly decrease the absorption of indinavir.
	Ritonavir can significantly increase levels of sildenafil.
	Lamivudine significantly lowers ritonavir levels.

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