Case 1: Drug Interactions with Antiretroviral Medications

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OIs: Treatment
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Antiretroviral Rx: Resistance
Antiretroviral Rx: Adverse Effects
Drug-Drug Interactions
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Question | Discussion | References | CME Credit

You answered:

	Lamivudine significantly lowers ritonavir levels.

This answer is incorrect. Lamivudine is not a substrate of CYP3A4 and is not know to affect the absorption of ritonavir. There are no known significant interactions between lamivudine and ritonavir. In general, lamivudine is considered to cause minimal (if any) drug-drug interactions.

Choose another answer:

	Didanosine enteric-coated capsules (Videx EC) will markedly decrease the absorption of indinavir.
	Ritonavir can significantly increase levels of sildenafil.
	Ritonavir significantly decreases the half-life of indinavir.

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