Case 3: Antiretrovirals and Methadone

Case-Based Modules
Initial Evaluation
Dermatologic Manifestations
Oral Manifestations
OIs: Prophylaxis
OIs: Treatment
Antiretroviral Rx
Antiretroviral Rx: Resistance
Antiretroviral Rx: Adverse Effects
Drug-Drug Interactions
Postexposure Prophylaxis
Perinatal Transmission
Special Populations
Prevention for Positives
Challenging Unknowns
Interactive Tutorials
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Question | Discussion | References | CME Credit

You answered:

	Methadone can reduce the plasma levels of didanosine.

This answer is incorrect. The enteric-coated didanosine (Videx EC) formulation has minimal interaction with methadone and has negligible impact on didanosine plasma levels. Methadone, however, decreases levels of the older buffered formulations of didanosine (Videx) and would require a didanosine dose increase.

Choose another answer:

	Nevirapine can reduce the plasma levels of methadone.
	Methadone can reduce levels of zidovudine.
	Lansoprazole can decrease absorption of methadone.

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