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Case 3: Antiretrovirals and Methadone

You answered:

B Nevirapine can reduce the plasma levels of methadone.

This answer is correct. The major biotransformation of methadone is through the 2B6 cytochrome pathway. Nevirapine is a known inducer of CYP2B6. Thus, plasma levels of methadone can significantly decrease with concomitant administration of nevirapine and methadone.


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