- Case-Based Modules
- Initial Evaluation
- Dermatologic Manifestations
- Oral Manifestations
- OIs: Prophylaxis
- OIs: Treatment
- Antiretroviral Rx
- Antiretroviral Rx: Resistance
- Antiretroviral Rx: Adverse Effects
- Drug-Drug Interactions
- Postexposure Prophylaxis
- Perinatal Transmission
- Special Populations
- Prevention for Positives
- Challenging Unknowns
- Resource-Limited Settings
- Interactive Tutorials
- Routine HIV Screening
- Oraquick Advance Rapid HIV Test
- HIV Integration
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Drug-Drug Interactions
Question | Discussion | References | CME Credit
Case 3: Antiretrovirals and Methadone
You answered:
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Decrease her dose of methadone |
|---|
This answer is incorrect. The symptoms the patient is experiencing are consistent with opioid withdrawal and this likely has resulted from a drug-drug interaction between efavirenz and methadone. Lowering her dose of methadone will make the situation worse.
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Immediately stop the antiretroviral regimen |
|---|---|
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Increase her dose of methadone |
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Start a benzodiazepine to treat her anxiety |
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