Case 3: Antiretrovirals and Methadone

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Case last updated: June 30, 2004

A 32-year-old male with a CD4 cell count of 215 cells/mm3 presents to clinic two weeks after starting his new antiretroviral regimen. He states she has been taking all of his medications. He is currently on a methadone maintenance program. Over the past few days he has been experiencing, chills with sweating, anxiety, diarrhea, and tremors. He now wants to stop his new antiretrovirals so he can feel "good" again.

Current Medications:

Didanosine (Videx EC): 400 mg PO qd
Zidovudine (Retrovir): 300 mg PO bid
Nevirapine (Viramune): 200 mg PO bid
Methadone (Methadose): 95mg PO qd
Lansoprazole (Prevacid): 30 mg PO qd

Which of the following is TRUE regarding a potential significant drug-drug interaction?

	Methadone can reduce the plasma levels of didanosine.
	Nevirapine can reduce the plasma levels of methadone.
	Methadone can reduce levels of zidovudine.
	Lansoprazole can decrease absorption of methadone.