Learning Objectives

Upon completing the module Drug-Drug Interactions, participants should be able to:

  1. Describe the interaction between ritonavir (Norvir) and sildenafil (Viagra).
  2. List the potential benefits of pharmacokinetic enhancement with ritonavir when used with another protease inhibitor.
  3. Understand the drug-drug interactions that occur with rifamycins (rifampin and rifabutin) and the non-nucleoside reverse transcriptase inhibitors (NNRTIs).
  4. Understand the drug-drug interactions that occur with rifamycins (rifampin and rifabutin) and the protease inhibitors (PIs).
  5. Summarize the impact of that nevirapine (Viramune) and efavirenz (Sustiva) have on methadone (Methadose) levels.
  6. Understand the interaction between protease inhibitors and methadone can be highly variable.
  7. Discuss the predicted impact of nevirapine (Viramune) and efavirenz (Sustiva) on oral contraceptive levels.
  8. Understand the recommendation to avoid using oral contraceptives as the primary form of birth control in persons taking either a non-nucleoside reverse transcriptase inhibitor (NNRTIS) or a protease inhibitor.
  9. Summarize the major interactions between statin drugs and antiretroviral medications.
  10. List 2 statin drugs that should be avoided when used in a patient taking antiretroviral regimen that contains a PI.