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Case 1: References

  1. Kahn JO, Walker BD. Acute human immunodeficiency virus type 1 infection. N Engl J Med. 1998;339:33-9.
    [The following link will open in a new window. PubMed Abstract]
  2. Schacker T, Collier AC, Hughes J, Shea T, Corey L. Clinical and epidemiologic features of primary HIV infection. Ann Intern Med. 1996;125:257-64.
    [The following link will open in a new window. PubMed Abstract]
  3. Vanhems P, Hughes J, Collier AC, et al. Comparison of clinical features, CD4 and CD8 responses among patients with acute HIV-1 infection from Geneva, Seattle and Sydney. AIDS. 2000;14:375-81.
    [The following link will open in a new window. PubMed Abstract]
  4. Daar ES, Little S, Pitt J, et al. Diagnosis of primary HIV-1 infection. Los Angeles County Primary HIV Infection Recruitment Network. Ann Intern Med. 2001;134:25-9.
    [The following link will open in a new window. PubMed Abstract]
  5. Newton PJ, Newsholme W, Brink NS, Manji H, Williams IG, Miller RF. Acute meningoencephalitis and meningitis due to primary HIV infection. BMJ. 2002;325:1225-7.
    [The following link will open in a new window. PubMed Abstract]
  6. Hecht FM, Busch MP, Rawal B, et al. Use of laboratory tests and clinical symptoms for identification of primary HIV infection. AIDS. 2002;16:1119-29.
    [The following link will open in a new window. PubMed Abstract]
  7. Pincus JM, Crosby SS, Losina E, King ER, LaBelle C, Freedberg KA. Acute human immunodeficiency virus infection in patients presenting to an urban urgent care center. Clin Infect Dis. 2003;37:1699-704.
    [The following link will open in a new window. PubMed Abstract]
  8. Henrard DR, Phillips JF, Muenz LR, Blattner WA, Wiesner D, Eyster ME, Goedert JJ. Natural history of HIV-1 cell-free viremia. JAMA. 1995;274:554-8.
    [The following link will open in a new window. PubMed Abstract]
  9. Dorrucci M, Rezza G, Vlahov D, et al. Clinical characteristics and prognostic value of acute retroviral syndrome among injecting drug users. Italian Seroconversion Study. AIDS. 1995;9:597-604.
    [The following link will open in a new window. PubMed Abstract]
  10. Schacker TW, Hughes JP, Shea T, Coombs RW, Corey L. Biological and virologic characteristics of primary HIV infection. Ann Intern Med. 1998;128:613-20.
    [The following link will open in a new window. PubMed Abstract]
  11. Spira AI, Marx PA, Patterson BK, Mahoney J, Koup RA, Wolinsky SM, Ho DD. Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques. J Exp Med. 1996;183:215-25.
    [The following link will open in a new window. PubMed Abstract]
  12. Sugaya M, Lore K, Koup RA, Douek DC, Blauvelt A. HIV-infected Langerhans cells preferentially transmit virus to proliferating autologous CD4(+) memory T cells located within Langerhans cell-T cell clusters. J Immunol. 2004;172:2219-24.
    [The following link will open in a new window. PubMed Abstract]
  13. Niu MT, Stein DS, Schnittman SM. Primary human immunodeficiency virus type 1 infection: review of pathogenesis and early treatment intervention in humans and animal retrovirus infections. J Infect Dis. 1993;168:1490-501.
    [The following link will open in a new window. PubMed Abstract]
  14. Letvin NL, Walker BD. Immunopathogenesis and immunotherapy in AIDS virus infections. Nat Med. 2003;9:861-6.
    [The following link will open in a new window. PubMed Abstract]
  15. Koup RA, Safrit JT, Cao Y, et al. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol. 1994;68:4650-5.
    [The following link will open in a new window. PubMed Abstract]
  16. Lyles RH, Munoz A, Yamashita TE, et al. Natural history of human immunodeficiency virus type 1 viremia after seroconversion and proximal to AIDS in a large cohort of homosexual men. Multicenter AIDS Cohort Study. J Infect Dis. 2000;181:872-80.
    [The following link will open in a new window. PubMed Abstract]
  17. Pantaleo G, Demarest JF, Schacker T, et al. The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. Proc Natl Acad Sci U S A. 1997;94:254-8.
    [The following link will open in a new window. PubMed Abstract]
  18. Walker BD, Goulder PJ. AIDS. Escape from the immune system. Nature. 2000;407:313-4.
    [The following link will open in a new window. PubMed Abstract]
  19. Patke DS, Langan SJ, Carruth LM, et al. Association of Gag-specific T lymphocyte responses during the early phase of human immunodeficiency virus type 1 infection and lower virus load set point. J Infect Dis. 2002;186:1177-80.
    [The following link will open in a new window. PubMed Abstract]
  20. Rich JD, Merriman NA, Mylonakis E, Greenough TC, Flanigan TP, Mady BJ, Carpenter CC. Misdiagnosis of HIV infection by HIV-1 plasma viral load testing: a case series. Ann Intern Med. 1999;130:37-9.
    [The following link will open in a new window. PubMed Abstract]
  21. Fiebig EW, Wright DJ, Rawal BD, et al. Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection. AIDS. 2003;17:1871-9.
    [The following link will open in a new window. PubMed Abstract]
  22. Rawal BD, Degula A, Lebedeva L, Janssen RS, Hecht FM, Sheppard HW, Busch MP. Development of a new less-sensitive enzyme immunoassay for detection of early HIV-1 infection.  J Acquir Immune Defic Syndr. 2003;33:349-55.
    [The following link will open in a new window. PubMed Abstract]
  23. Kassutto S, Johnston MN, Rosenberg ES. Incomplete HIV type 1 antibody evolution and seroreversion in acutely infected individuals treated with early antiretroviral therapy. Clin Infect Dis. 2005;40:868-73.
    [The following link will open in a new window. PubMed Abstract]
  24. Killian MS, Norris PJ, Rawal BD, Lebedeva M, Hecht FM, Levy JA, Busch MP. The effects of early antiretroviral therapy and its discontinuation on the HIV-specific antibody response.  AIDS Res Hum Retroviruses. 2006;22:640-7.
    [The following link will open in a new window. PubMed Abstract]
  25. Hare CB, Pappalardo BL, Busch MP, et al. Seroreversion in subjects receiving antiretroviral therapy during acute/early HIV infection.  Clin Infect Dis. 2006;42:700-8.
    [The following link will open in a new window. PubMed Abstract]

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