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Case 4: Latent Tuberculosis Infection

You answered:

A After excluding active TB with a symptom review and a chest radiograph, you should treat him with 9 months of isoniazid (INH).

This answer is correct. Prior to giving isoniazid (INH) for latent TB infection, active TB should be excluded by symptom review and by chest radiograph. If this patient has no evidence of active TB, they should be treated for latent TB infection. This patient is presumed to have latent TB infection based on the close exposure to his partner with active pulmonary TB. In this situation, the patient is considered to have latent TB infection regardless of his tuberculin skin test result. For HIV-infected persons, 9 months of INH is appropriate therapy for latent TB infection.


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