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Case 8: A 27-Year-Old Man with AIDS and Disseminated Histoplasmosis

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C For patients taking itraconazole maintenance therapy, serum itraconazole levels should be monitored, at least initially.

This answer is correct. Monitoring serum itraconazole levels during maintenance therapy is recommended, and although required levels have not been exactly defined, patients should generally have a random serum itraconazole level of at least 1.0 μg/mL. Achieving serum itraconazole levels greater than 10 μg/mL is unnecessary and leads to greater toxicity.

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