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Case 9: Cryptosporidiosis in a Patient with AIDS

You answered:

C Recommended treatment consists of high-dose trimethoprim-sulfamethoxazole (Bactrim, Septra).

This answer is incorrect. Although trimethoprim-sulfamethoxazole is a first-line therapy for the treatment of Cystoisospora (Isospora) gastrointestinal infection, it has no established benefit for the treatment of Cryptosporidum infection.

A Most patients acquire Cryptosporidium from exposure to undercooked meat.
B Among antimicrobial agents studied for the treatment of cryptosporidiosis, the combination of azithromycin (Zithromax) plus paromomycin (Humatin) is the most effective therapy.
D Immune restoration with antiretroviral therapy is considered essential in the management of patients with cryptosporidiosis.

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