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Case 2: Initial Evaluation and Postexposure Prophylaxis

You answered:

C A two-drug PEP regimen should be initiated immediately.

This answer is incorrect. The 2005 U.S. Public Health Service guidelines suggest that a more aggressive, three-drug PEP regimen should be recommended for either a high-risk exposure or exposure involving a source patient who is classified as high-risk. Both the exposure and the source patient in the case presented would be regarded as high risk.

A PEP is not indicated at this time because too much time has elapsed since the exposure.
B PEP should be initiated if viral load testing on the source patient reveals a high viral load.
D A three-drug PEP regimen should be initiated immediately.

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