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Case 4: STDs and HIV Transmission

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A The presence of genital lesions caused by HSV in an HIV-infected person confers a major increase (up to 4-fold) in the risk of HIV transmission to a HIV-negative partner.

This answer is correct. The presence of a recent genital ulcer caused by HSV is associated with an approximate 4-fold increased risk of transmission of HIV per-sex-act in couples who are serodiscordant for both HIV and HSV-2.

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