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Case 4: Transgender Women and HIV

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C Anti-androgen therapy with spironolactone (Aldactone) is often used as part of hormonal gender reassignment therapy to further decrease male secondary sexual characteristics.

This answer is correct. Many patients receiving hormonal gender reassignment therapy will take anti-androgen therapy to diminish male secondary sexual characteristics. Spironolactone is the most common agent used for this purpose, but it should not be used in persons with renal failure or who have a potassium level greater than 5.5 mEq/L.

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