Question | Discussion | References | CME Credit

Case 3: A 44-Year-Old with Unusual Changes in Physical Appearance

You answered:

B Cushing’s syndrome caused by an interaction between fluticasone and ritonavir.

This answer is correct. Ritonavir is a potent inhibitor of the CYP 3A4 enzyme; it can significantly increase systemic levels of fluticasone, a potent inhaled corticosteroid. This interaction can lead to hypercortisolism and symptoms of Cushing’s syndrome.


[Back to Case 3 Question | Proceed to Case 3 Discussion]