- Case-Based Modules
- Initial Evaluation
- Dermatologic Manifestations
- Oral Manifestations
- OIs: Prophylaxis
- OIs: Treatment
- Antiretroviral Rx
- Antiretroviral Rx: Resistance
- Antiretroviral Rx: Adverse Effects
- Drug-Drug Interactions
- Postexposure Prophylaxis
- Perinatal Transmission
- Special Populations
- Prevention for Positives
- Challenging Unknowns
- Resource-Limited Settings
- Interactive Tutorials
- Routine HIV Screening
- Oraquick Advance Rapid HIV Test
- HIV Integration
- This program is funded through Health Resources and Services Administration, US Department of Health and Human Services.
Challenging Unknowns
Question | Discussion | References | CME Credit
Case 3: A 44-Year-Old with Unusual Changes in Physical Appearance
You answered:
 |
Cushing’s syndrome caused by an interaction between fluticasone and ritonavir. |
|---|
This answer is correct. Ritonavir is a potent inhibitor of the CYP 3A4 enzyme; it can significantly increase systemic levels of fluticasone, a potent inhaled corticosteroid. This interaction can lead to hypercortisolism and symptoms of Cushing’s syndrome.
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