Saman Arbabi, MD, MPH, FACS
Associate Professor, Department of Surgery
The innate immune response is designed to focus a controlled inflammatory effort in a spatially localized manner. Subsequent systemic inflammation can be seen as an uncontrolled or overwhelming response. Using a burn model, our lab investigates the systemic and local effects of modifying inflammatory signaling. We have demonstrated that a topical application of p38 MAPK, an inflammatory signaling cascade, attenuates acute lung injury and organ dysfunction.