Raimondo D'Ambrosio, PhD
Associate Professor, Department of Neurological Surgery
Our laboratory's activity focuses on the acute and chronic neuropathophysiology of traumatic head injury, with the ultimate goal to identify novel cellular targets for improved therapeutic intervention. To this end, we are currently studying the pathophysiological changes that occur at the molecular level in the membranes of glial cells and neurons in rat posttraumatic brain. We have developed a clinically-relevant model of posttraumatic epilepsy in the rat that we are using to identify clinically-relevant epileptogenic mechanisms and the first antiepileptogenic drugs. Principal techniques used in the lab are: 1) Patch clamp recordings from in situ neurons and glia in brain slices; 2) Ion-selective-microelectrode recordings for measurement of brain extracellular space ion homeostasis; 3) Video-EEG monitoring for in vivo seizure detection and characterization, 4) High Performance Liquid Chromatography, for measuring biochemical markers of head injury and epilepsy.