Loren Engrav, MD
Professor, Department of Surgery
Hypertrophic scarring is a devastating sequel of thermal injury; the etiology is unknown and treatment is minimally effective. A major reason for our ignorance has been the absence of a useful animal model. We (and Hart from Canada) have now validated the Duroc/Yorkshire model of fibroproliferative scarring. In addition, we have demonstrated that the cones of the dermis occur in the same body locations as hypertrophic scarring. We have obtained tissue from shallow and deep partial-thickness wounds on Duroc and Yorkshire pigs, extracted and amplified the mRNA, and hybridized the Affymetrix Porcine GeneChip. We are now assembling gene expression pathways that might be responsible for fibroproliferative scarring.