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Nonoxynol-9 Couples Study |
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Acceptability of a bioadhesive nonoxynol-9 gel delivered by an applicator as a rectal microbicide.
Source:
Sex Transm Dis 1999 Nov;26(10):572-8
Authors:
Gross M, Celum CL, Tabet SR, Kelly CW, Coletti AS, Chesney MA.
Publication Info:
Abt Associates Inc., Bethesda, Maryland 20814, USA.
Abstract:
BACKGROUND AND OBJECTIVES: Potential rectal microbicides, as an adjunct to condoms for
HIV/STD prevention, have not been studied previously. GOAL OF THIS STUDY: Advantage 24
(1.5 ml of a bioadhesive gel containing 52.5 mg nonoxynol-9 administered by single-use
applicator)-under investigation as a vaginal microbicide-was evaluated for acceptability
among male couples. STUDY DESIGN: Twenty-five HIV-negative and 10 HIV-positive male
couples participated in a frequency use escalation trial. Diaries and self-administered
questionnaires assessed product use, acceptability, sexual behavior, and
gastrointestinal and urologic side effects. RESULTS: Excluding participants who felt no
need for an HIV prevention method, 58% said they would use Advantage 24 if approved for
rectal use; 69% of receptive users reported rectal fullness and related side effects
after insertion of the gel, and 68% reported applicator-related discomfort; 59% of
insertive participants found the gel too sticky. CONCLUSIONS: Acceptability remains
inconclusive and warrants further study of redesigned applicators and ways to minimize
rectal side effects.
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