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Correlates of Prevalent and Incident Kaposi's Sarcoma-Associated Herpesvirus Infection in Men Who Have Sex with Men.
Source:
J Infect Dis 2002 Apr 1;185(7):990-3
Authors:
Casper C, Wald A, Pauk J, Tabet SR, Corey L, Celum CL
Publication Info:
Department of Medicine, University of Washington, Seattle, WA
98195, USA. ccasper@u.washington.edu[Confidentiality cannot be guaranteed for
information provided via e-mail. People visiting websites from public or work
machines may be leaving traces of their visits on those machines.]
Abstract:
Infection with Kaposi's sarcoma-associated herpesvirus (KSHV) is common among men
who have sex with men (MSM). To determine correlates of infection, 578 human
immunodeficiency virus (HIV)-negative MSM were assessed by serologic assays,
questionnaires, and physical examinations. At baseline, 76 (16%) of 474 participants
were KSHV seropositive. Prevalent KSHV infection was significantly associated with
hepatitis A (odds ratio [OR], 3.3; 95% confidence interval [CI], 1.5-7.5), hepatitis
B seropositivity (OR, 2.6; 95% CI, 1.4-4.8), herpes simplex virus (HSV)-2 (OR, 2.4;
95% CI, 1.3-4.4), and >4 male partners in the previous 6 months (OR, 1.9; 95% CI,
1.1-3.2). Fifteen KSHV seroconversions (4%) were observed for an incidence of
3.8/100 person-years, similar to HSV-1 incidence in this cohort and more frequent
than incidence of HIV and HSV-2. Reporting >/=1 HIV-positive partner (OR, 5.9; 95%
CI, 1.8-19.3), amyl nitrite use (OR, 7.0; 95% CI, 2.1-23.0), and lymphadenopathy in
the past 6 months (OR, 7.7; 95% CI, 1.9-31.0) correlated with KSHV seroconversion.
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