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Be A Hero Vaccine Preparedness Study |
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Readiness for HIV vaccine trials: changes in willingness and knowledge among high-risk populations in the HIV network for prevention trials. The HIVNET Vaccine Preparedness Study Protocol Team.
Source:
J Acquir Immune Defic Syndr 2000 Aug 15;24(5):451-7
Authors:
Koblin BA, Holte S, Lenderking B, Heagerty P.
Publication Info:
Laboratory of Epidemiology, The New York Blood Center, New York, New York 10021,
USA.
Abstract:
Longitudinal data were analyzed to determine changes in willingness to participate
in HIV vaccine efficacy trials and knowledge of vaccine trial concepts among
populations at high risk of HIV-1 infection. Gay men (MSM), male and female
injection drug users, and non-injecting women at heterosexual risk were recruited (n
= 4892). Follow-up visits occurred every 6 months up to 18 months. Willingness was
significantly lower at follow-up visits compared with at baseline. Knowledge levels
increased for all study populations. Problematic concepts were possible effects of
the vaccine on the immune system and lack of knowledge about efficacy of a vaccine
before the start of a trial. For concepts concerning safety, blinding, and
guarantees of future participation in trials, MSM men had significant increases in
knowledge, but little to no change occurred for the other populations. An increase
in knowledge was associated with becoming not willing, particularly among MSM with
low knowledge levels. At least half of high-risk participants were consistently
willing to participate in future vaccine efficacy trials and with basic vaccine
education, knowledge levels increased. Continued educational efforts at the
community and individual level are needed to address certain vaccine trial concepts
and to increase knowledge levels in all potential study populations.
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