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Be A Hero Vaccine Preparedness Study |
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Rectal microbicides for U.S. gay men. Are clinical trials needed? Are they feasible? HIVNET Vaccine Preparedness Study Protocol Team.
Source:
Sex Transm Dis 1998 Jul;25(6):296-302
Authors:
Gross M, Buchbinder SP, Celum C, Heagerty P, Seage GR 3rd.
Publication Info:
Abt Associates Inc, Cambridge, Massachusetts, USA.
Abstract:
BACKGROUND AND OBJECTIVES: Incomplete condom use during anal sex persists among gay
men; microbicides may provide additional protection. Despite the absence of efficacy
or safety data, many gay men use sexual lubricants containing nonoxynol-9 (N-9), a
detergent-based spermicide under evaluation for efficacy as a vaginal microbicide.
GOAL: Evaluate unprotected sex, lubricant use, and attitudes regarding possible
participation in clinical trials of rectal microbicides among high-risk human
immunodeficiency virus-(HIV) seronegative U.S. gay men in six cities. STUDY DESIGN:
A total of 3,257 gay men were interviewed and responded to a self-administered
questionnaire at enrollment into a longitudinal cohort study of HIV seroincidence.
RESULTS: Among 2,216 men who practiced receptive anal intercourse in the previous 6
months, 438 (20%) reported they never used condoms. More than three fourths of 3,093
men who had anal sex used lubricants more than 80% of the time. 41% of whom actively
sought N-9 containing products. About two thirds said they were definitely or
probably willing to participate in rectal microbicide clinical trials. CONCLUSION:
Condom use is imperfect among men who report anal sex. N-9 lubricants are popular.
Most gay men in this cohort indicate willingness to participate in rectal
microbicide studies.
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