Larry Kessler

faculty photo
Professor, Health Services
Adjunct Professor, Pharmacy

Education

ScD   Johns Hopkins University, 1978   (Health Services Admin)
BS   Boston University, 1973   (Mathematics)

Contact Info

email:   kesslerl@uw.edu

office:   F-351E, Health Sciences Building

address:
University of Washington
Department of Health Services
Seattle, WA 98195-3660

campus box:   357660
voice:   206-543-2703

About

Larry Kessler is a former Chair of the Department of Health Services. He served as Director of the Office of Surveillance and Biometrics, Center for Devices and Radiological Health, FDA until 2008. From 1984 to 1995, he headed and developed the Applied Research Branch at NCI. In 2001, he spent a year as a visiting scientist at the Fred Hutchinson Cancer Research Center and served on the faculty of the Department of Health Services.


Cost-effectiveness and diagnostic value of medical technology in screening for cancer and other diseases

  • HSERV 511
    Introduction to Health Services and Public Health
  • HSERV 512
    Health Systems and Policy
  • HSERV 578
    Preparing, Writing, and Critiquing Scientific Research Proposals


Zeitler EP, Al-Khatib SM, Drozda JP Jr, Kessler LG, Kirtane AJ, Kong DF, Laschinger J, Marinac-Dabic D, Morice MC, Reed T, Sedrakyan A, Stein KM, Tcheng J, Krucoff MW; MDEpiNet. Predictable and SuStainable Implementation of National Cardiovascular Registries (PASSION) infrastructure: A think tank report from Medical Device Epidemiological Network Initiative (MDEpiNet). Am Heart J. 2016 Jan;171(1):64-72.e2. doi: 10.1016/j.ahj.2015.07.029. Epub 2015 Jul 30.  PMID: 26699602    PMCID: PMC4692177
   


Sullivan DC, Obuchowski NA, Kessler LG, Raunig DL, Gatsonis C, Huang EP, Kondratovich M, McShane LM, Reeves AP, Barboriak DP, Guimaraes AR, Wahl RL; RSNA-QIBA Metrology Working Group. Metrology Standards for Quantitative Imaging Biomarkers. Radiology. 2015 Aug 12:142202. [Epub ahead of print]  PMID: 26267831    PMCID: PMC4666097
   


Potosky AL, O'Neill SC, Isaacs C, Tsai HT, Chao C, Liu C, Ekezue BF, Selvam N, Kessler LG, Zhou Y, Schwartz MD. Population-based study of the effect of gene expression profiling on adjuvant chemotherapy use in breast cancer patients under the age of 65 years. Cancer. 2015 Aug 20. doi: 10.1002/cncr.29621. [Epub ahead of print]  PMID: 26291519    PMCID: PMC4635042
   


Jarvik JG, Comstock BA, James KT, Avins AL, Bresnahan BW, Deyo RA, Luetmer PH, Friedly JL, Meier EN, Cherkin DC, Gold LS, Rundell SD, Halabi SS, Kallmes DF, Tan KW, Turner JA, Kessler LG, Lavallee DC, Stephens KA, Heagerty PJ. Lumbar Imaging With Reporting Of Epidemiology (LIRE)-Protocol for a pragmatic cluster randomized trial. Contemp Clin Trials. 2015 Nov;45(Pt B):157-63. doi: 10.1016/j.cct.2015.10.003. Epub 2015 Oct 19.  PMID: 26493088    PMCID: PMC4674321
   


O'Neill SC, Isaacs C, Chao C, Tsai HT, Liu C, Ekezue BF, Selvam N, Kessler LG, Schwartz MD, Lobo T, Potosky AL. Adoption of Gene Expression Profiling for Breast Cancer in US Oncology Practice for Women Younger Than 65 Years. J Natl Compr Canc Netw. 2015 Oct;13(10):1216-24.  PMID: 26483061
 


A Pragmatic Trial of Lumbar Image Reporting with Epidemiology
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
PI:   Jarvik           Dates:    1/1/2016 - 12/31/2016

Comparing Outcomes of Drugs and Appendectomy (CODA)
Patient-Centered Outcomes Research Institute (PCORI)
PI:   Flum           Dates:    10/1/2015 - 9/30/2020

Topical Antibiotic Treatment for Spine Surgical Site Infections
National Institutes of Health (NIH)
PI:   Flum           Dates:    7/1/2015 - 6/30/2017

Practice Patterns and Impact of Operative and Non-operative Management of Diverticulitis
National Institutes of Health (NIH)
PI:   Flum           Dates:    7/1/2015 - 6/30/2020

Institute of Translational Health Sciences (ITHS)
National Center for Advancing Translational Sciences (NCATS)
PI:   Disis           Dates:    6/1/2015 - 5/31/2016

Translational Research Center to Expedite Novel Therapies in Cystic Fibrosis
Seattle Children's Hospital Research Institute
PI:   Greenberg           Dates:    6/1/2015 - 5/31/2020

A new Nanotechnology Therapy for Glioblastoma and Prostate Cancer
MagForce USA, Inc.
PI:   Kessler           Dates:    3/1/2015 - 12/31/2015

A Pragmatic Trial of Lumbar Image Reporting with Epidemiology (LIRE)
National Institutes of Health (NIH)
PI:   Jarvik           Dates:    1/1/2015 - 12/31/2015

A new Nanotechnology Therapy for Glioblastoma and Prostate Cancer
MagForce USA, Inc.
PI:   Kessler           Dates:    10/1/2014 - 6/30/2015

VA Services agreement 2014 - 15
VA Puget Sound Health Care System (VAPSHCS)
PI:   Kessler           Dates:    9/1/2014 - 8/31/2015

VA Services Agreement 2014 - 15 - Supplement
VA Puget Sound Health Care System (VAPSHCS)
PI:   Kessler           Dates:    9/1/2014 - 8/31/2015

Cancer Consortium Non-Competing Renewal 2014
Fred Hutchinson Cancer Research Center (FHCRC)
PI:   Bremner           Dates:    1/1/2014 - 12/31/2014

A Pragmatic Trial of Lumbar Image Reporting with Epidemiology (LIRE)
National Center for Complementary and Alternative Medicine (NCCAM)
PI:   Jarvik           Dates:    1/1/2014 - 12/31/2017

LSDF SCOAP CER Network
Washington State Life Sciences Discovery Fund Authority (LSDFA)
PI:   Flum           Dates:    10/16/2013 - 10/15/2015

VA Services agreement 2013 - 14
VA Puget Sound Health Care System (VAPSHCS)
PI:   Kessler           Dates:    10/1/2013 - 9/30/2014

Abridged Topic Development of PCORI Research Topics: Improving Health Systems
Oregon Health and Science University (OHSU)
PI:   Carlson           Dates:    9/6/2013 - 9/5/2014

Long Term Outcomes of Lumbar Epidural Steroid Injections for Spinal Stenosis
Patient-Centered Outcomes Research Institute (PCORI)
PI:   Friedly           Dates:    5/1/2013 - 4/30/2016

Consortium Cancer Center Support Grant 2013
Fred Hutchinson Cancer Research Center (FHCRC)
PI:   Bremner           Dates:    1/1/2013 - 12/31/2013

Surveillance Trial to Increase Longevity in Lung Cancer Patients (STILL)
American College of Radiology (ACR)
PI:   Kessler           Dates:    12/1/2012 - 2/28/2013

VA Service Agreement 2009
VA Puget Sound Health Care System (VAPSHCS)
PI:   Kessler           Dates:    10/1/2012 - 9/30/2013

ARRA Multi-Payer Claims Database (“MPCD”) Implementation – University of Washington Subcontract
IPSS Ingenix Public Sector Solutions, Inc.
PI:   Kessler           Dates:    3/19/2012 - 9/15/2013

Comparative Effectiveness of Dynamic Patterns of Glucose Lowering Therapies
University of Chicago
PI:   Kessler           Dates:    7/1/2011 - 6/30/2015

Surgical Care and Outcomes Assessment Program Comparative Effectiveness Research Translation Network (SCOAP CERTN)
Agency for Healthcare Research and Quality (AHRQ)
PI:   Flum           Dates:    11/1/2010 - 10/31/2013

Back pain Outcomes using Longitudinal Data (BOLD)
Agency for Healthcare Research and Quality (AHRQ)
PI:   Jarvik           Dates:    9/1/2010 - 8/31/2013

National Emphysema Treatment Trial

Collaborating on a cost-effectiveness study of a very controversial surgical treatment for emphysema patients.


CanCORS

Collaborating on studies of outcomes and patterns of care of both colorectal cancer and lung cancer. We are looking into what kinds of treatment certain types of patients receive and how we can improve the process of obtaining the best cancer care.


CISNET

Collaborating on a study focused on the tremendous increase in the rate of prostate cancer incidence during the 1990's. Much of this disease may represent 'overdiagnosis' which is accompanied by significant loss of quality of life in many cases.