Ann Melvin MD, MPH

Ann Melvin MD, MPH
Associate Professor
Email: click here
Phone: (206) 987-2535

Dr. Melvin received her MD and MPH from Tulane University in 1986. After an internship at the University of California, San Francisco, she transferred to the University of Washington where she completed her residency and fellowship. She joined the division in 1993. Dr. Melvin provides primary care services for HIV-infected children and adolescents as well as HIV-exposed infants. Her research effort focuses on clinical trials in HIV-infected and exposed children to prevent perinatal HIV transmission and to investigate the optimal management strategies for long-term health for these children. Through the International Maternal Pediatric Adolescent Clinical Trials Group, she is co-chair of an international trial looking at different treatment strategies for HIV-1-infected children. Dr. Melvin is also interested in international health and is currently the director of an educational and research exchange program with the Tamilnadu Dr. MGR Medical University in Chennai funded through the University of Washington, Puget Sound Partners for Global Health.

Undergraduate
Kansas State University, B.S., 1980
Oxford University, England, B.A., 1982

Medical School
Tulane University School of Medicine, 1986

Tulane University School of Public Health and Tropical Medicine, M.P.H., 1986

Residency
University of California, San Francisco, Intern, 1986-87

Children's Hospital and Regional Medical Center/University of Washington, 1987-89

Fellowship
Children's Hospital and Regional Medical Center/University of Washington, 1989-92

Clinical studies of HIV infection.

Melvin, A. J., P. F. Lewis, K. M. Mohan, W. S. Naugler, and L. M. Frenkel. 2002. Efficacy and toxicity of antiretroviral therapy using 4 or more agents: application of a strategy for antiretroviral management in human immunodeficiency virus-infected children. Arch Pediatr Adolesc Med 156:568-73.

Krogstad P, Lee S, Johnson G, Nachman S, et al and Wiznia AA for the Pediatric AIDS Clinical Trials Group Study Team. 2002. Combination nucleoside analogue(s) reverse transcriptase inhibitors plus nevirapine, nelfinavir or ritonavir in stable antiretroviral therapy-experienced HIV-infected children. Week 48 analysis of Pediatric AIDS Clinical Trials Group 377. (Melvin A.J.) Clinical Infectious Diseases 34:991-1001.

Frenkel, L. M., Y. Wang, G. H. Learn, J. L. McKernan, G. M. Ellis, K. M. Mohan, S. E. Holte, S. M. De Vange, D. M. Pawluk, A. J. Melvin, P. F. Lewis, L. M. Heath, I. A. Beck, M. Mahalanabis, W. E. Naugler, N. H. Tobin, and J. I. Mullins. 2003. Multiple viral genetic analyses detect low-level human immunodeficiency virus type 1 replication during effective highly active antiretroviral therapy. J Virol 77:5721-30.

Melvin, A. J., and K. M. Mohan. 2003. Response to immunization with measles, tetanus, and Haemophilus influenzae type b vaccines in children who have human immunodeficiency virus type 1 infection and are treated with highly active antiretroviral therapy. Pediatrics 111:e641-4.

Flynn PM, Rudy BJ, Douglas SD, Lathey J, Spector SA, Martinez J, Silio M, Belzer M, McNamara J, Hodge J, Hughes MD, Lindsey JC. (Melvin, A.J.) 2004. Virologic and immunologic outcome after 24 weeks in HIV-1 infected adolescents receiving highly active antiretroviral therapy. Journal of Infectious Diseases 190: 271-279.

Melvin, A. J., J. Alarcon, C. Velasquez, C. Rodriguez, J. Piscoya, A. Giraldo, P. Dinh, and L. M. Frenkel. 2004. Rapid HIV-1 Testing of Women Presenting in Late Pregnancy with Unknown HIV Status in Lima, Perú. AIDS and Hum Retro Res 20:1046-52.

Tobin NH, Learn GH, Holte SE, Wang Y, Melvin AJ, McKernan JL, Pawluk DM, Mohan KM, Lewis PF, Mullins JI, Frenkel LM. 2005. Evidence that Low-level Viremias During Effective HAART Result from Two Processes: Expression of Archival Virus and Replication of Virus. J Virol. 79:9625-34.

Johnson DC, McKarland EJ, Muresan P, Fenton T, McNamara J, Read JS, Hawkins E, Bouquin PL, Estep SG, Tomaras GD, Vincent CA, Rathore M, Melvin AJ, Gurunathan S, Lambert J. 2005. Safety and Immunogenicity of an HIV-1 Recombinant Canarypox Vaccine in Newborns and Infants of HIV-1 Infected Women. J Infect Dis 1992;2129-33.

Holte SE, Melvin AJ, Mullins JI, Tobin NH, Frenkel LM. 2006. Density-Dependent Decay in HIV-1 Dynamics. J. Acquir. Immun. Defic. Syndr. and Human Retrovirol; 41: 266-276.

Hitti J, Anderson J, McComsey G, Liu T, Melvin A, Smith L, Stek A, Aberg J, Hull A, Alston-Smith B, Watts H, Livington E. Protease inhibitor-based antiretroviral therapy and glucose tolerance in pregnancy: AIDS Clinical Trials Group A5084. Am J Obstet Gynecol 2007;196;331.e1-331.e7.

Gupta D, Lhewa D, Viswanath R, Jacob SM, Parameshwari S, Radhakrishnan R, Seidel K, Frenkel L, Samuel NM, Melvin AJ. Effectiveness of antenatal group HIV voluntary counseling and testing (VCT) services in rural India. AIDS Education and Prevention. 2007;41: in press.