Hans Ochs MD

Hans Ochs MD
Professor
Email: click here
Phone: (206) 685-3412

Dr. Hans Ochs has developed a program to analyze the genetic and molecular basis of Primary Immunodeficiency disorders. Large databases have been generated to cover mutations in WASP, Btk, CD40 ligand, SAP, and other genes causing immune deficiencies. Most recently, his laboratory has focused on the newly discovered gene causing autosomal recessive hyper IgM syndrome (activation-induced cytidine deaminase, AID) and the scurfy gene, FOXP3, responsible for a syndrome involving immunodeficiency, polyendocrinopathy, enteropathy, X-linked (IPEX).

Dr. Ochs has an active immunodeficiency clinic where both pediatric and adult patients are seen. His laboratory is at the University of Washington Medical Center.

Rengan R, Ochs HD, Sweet LI, Keil ML, Gunning WT, Lachant NA, Boxer LA, Omann GM. Actin cytoskeletal function is pared, but apoptosis is increased, in WAS patient hematopoietic cells. Blood 95:1283-92, 2000.

Oda A, Ikeda Y, Ochs HD, Druker BJ, Ozaki K, Handa M, Ariga T, Sakiyama Y, Witte ON, Wahl MI. Rapid Tyrosine Phosphorylation and Activation of Btk/Tec kinases in Platelets Inudced by Collagen Binding or CD32 crosslinking. Blood 95:1663-70, 2000.

Rubinstein A, Mizrachi Y, Bernstein L, Shliozberg J, Golodner M, Cheng CJ, Liu G, Ochs HD. Progressive specific immune attrition following primary, secondary, and tertiary immunizations with bacteriophage φX174 in asymptomatic HIV infected subjects. AIDS 14:F55-F-62, 2000.

Raskind WH, Niakan KK, Wolff J, Matsushita M, Vaughan T, Stamatoyannopoulos G, Watanabe C, Rios J, Ochs HD: Mapping of a Syndrome of X-Linked Thrombocytopenia and Thalassemia to Xp11-12: Further Evidence for Genetic Heterogeneity of X-Linked Thrombocytopenia. Blood 95(7):2262-8, 2000.

Barry SC, Seppen J, Ramesh N, Foster JL, Seyama K, Ochs HD, Garcia JV, Osborne WR. Lentiviral and murine retroviral transduction of T cells for expression of human CD40 ligand. Hum Gene Ther 11:323-32, 2000.

Gottlieb A, Krueger J, Bright R, Ling M, Lebwohl M, Kang S, Feldman S, Spellman M, Wittkowski D, Ochs HD, Jardieu P, Bauer R, White M, Dedrick R, Garovoy M. Effects of Administration of a Single Dose of a Humanized Monoclonal Antibody to CD11a on the Immunobiology and Clinical Activity of Psoriasis. J Am Acad Dermatol 42:428-435, 2000.

Kanegane H, Nomura K, Miyawaki T, Sasahara Y, Kawai S, Tsuchiya S, Murakami G, Futatani T, Ochs, HD. X-linked thrombocytopenia identified by flow cytometric demonstration of defective Wiskott-Aldrich syndrome protein in lymphocytes. Blood 95:1110-1, 2000.

Itoh S, Nonoyama S, Morio T, Imai K, Okawa H, Ochs HD, Shimadzu M, Yata J. Mutations of the WASP gene in 10 Japanese patients with Wiskott-Aldrich syndrome and X-linked thrombocytopenia. Int J Hematol 71(1):79-83, 2000.

Fogelman I, Davey V, Elashoff M, Ochs HD, Feinberg MB, Mican JA, Siegel JP, Sneller M, Lane HC. Evaluation of CD4+ T-cell Function in vivo in HIV-infected Patients as Measured by Bacteriophage φX174 Immunization. J Infectious Disease 182:435-41, 2000.

Hartnett BJ, Somberg RL, Krakowka S, Moore PF, Ochs HD, HogenEsch H, Weinberg KI, Felsburg PJ. B-cell function in canine X-linked severe combined immunodeficiency. Vet Immunol, Immunopathol 75:121-134, 2000.

Winkelstein JA, Marino MC, Johnston Jr. R, Boyle J, Curnutte J, Gallin JI, Malech HL, Holland SM, Ochs HD, Quie P, Buckley RH, Foster CB, Chanock SJ, Dickler H: Chronic Granulomatous Disease: Report on a national registry of 368 patients. Medicine (Baltimore) 79(3):155-69, 2000.

Parolini S, Bottino C, Falco M, Augugliaro R, Giliani S, Franceschini R, Ochs HD, Wolf H, Bonnefoy JY, Biassoni R, Moretta L, Notarangelo LD, Moretta A. X-linked Lymphoproliferative Disease: 2B4 Molecules Displaying Inhibitory Rather Than Activating Function Are Responsible for the Inability of NK Cell to Kill EBV-infected Cells. J Exp Med 192:337-346, 2000.