Michael J. Bevan, PhD, FRS
Professor of Immunology, Investigator HHMI
Email: click here
Phone: (206) 685-3610
Studies the mechanisms underlying maturation, recognition, and homeostasis of cytotoxic T lymphocytes; the role of CD8+ T cells in host defense against viral and bacterial pathogens; and helper signals for forming robust CD8 memory. Dr. Bevan was among the first to describe the phenomenon of MHC-restricted antigen recognition by T lymphocytes, has been a driving force in the elucidation of mechanisms underlying T cell receptor repertoire selection in the thymus and periphery, and was the first to report “cross-priming.” His group has also recently shown that CD8 T cells responding to acute pathogens, such as Listeria monocytogenes or lymphocytic choriomeningitis virus, are dependent on signals from CD4 T cells to generate and maintain long-lived functional memory cells. Very recently, his work has shown that signals from IL-2 are an essential part of the initial response in programming CD8 T cells to full differentiation into memory cells that can respond on rechallenge. Recent studies from his lab have shed light on how the emerging T cell repertoire is purged of reactivity to self antigens that have tissue restricted expression. He collaborates with Drs. Urdahl, and Fink.
Hogquist KA, Jameson SC, Heath WR, Howard J, Bevan MJ, and Carbone FR. T cell receptor antagonist peptides induce positive selection. Cell 76:17-27, 1994.
Butz EA and Bevan MJ. Massive expansion of antigen specific CD8+ T cells during an acute virus infection. Immunity 8:167-175, 1998.
Goldrath AW and Bevan MJ. Selecting and maintaining a diverse T cell repertoire. Nature 402:255-262, 1999.
He YW, Beers C, Deftos ML, Ojala EW, Forbush KA, Bevan MJ. Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation. J Immunol 164(11):5668-74, 2000.
Deftos ML, Huang E, Ojala EW, Forbush KA, Bevan MJ. Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes. Immunity 13(1):73-84, 2000.
Goldrath AW, Bogatzki LY, Bevan MJ. Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-driven Proliferation. J Exp Med 192(4):557-564, 2000.