Craig Rubens, MD, PhD
Affiliate Professor; Executive Director, Global Alliance to Prevent Prematurity and Stillbirth
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Craig Rubens is co-founder and Executive Director of the Global Alliance to Prevent Prematurity and Stillbirth (GAPPS). This initiative was launched by Seattle Children’s Hospital to unravel the mysteries surrounding prematurity and stillbirth and to promote an aggressive research and development and advocacy agenda that will lead to prevention of these two significant global perinatal health problems. GAPPS’ Mission is to Improve Birth Outcomes Worldwide. Dr. Rubens is Professor in the Department of Global Health, and Professor of Pediatrics at University of Washington School of Medicine. He is a member of several prestigious societies, including the American Society of Clinical Investigators and the American Pediatric Society.
Dr. Rubens is a physician-scientist and Pediatric Infectious Disease specialist with a strong background in infectious diseases and microbiology. His research focus is on serious bacterial infections in childhood, primarily perinatal infections that lead to poor pregnancy and neonatal health outcomes. His research, based on the premise that the battle between infectious agents and the immune system is at the heart of disease, has focused on understanding the mechanisms of infection-induced preterm labor and severe neonatal infections.
GAPPS is leading a collaborative, global effort to increase awareness and accelerate innovative research and interventions that will improve maternal, newborn and child health outcomes around the world.
University of Washington, B.S., Microbiology, 1975
University of South Carolina, Ph.D., Department of Basic and Clinical Immunology and Microbiology, 1978
University of Washington, 1982
Children's Hospital and Regional Medical Center/University of Washington, 1983-84
Children's Hospital and Regional Medical Center/University of Washington, Infectious Disease, 1984-86
1. Cieslewicz MJ, Chaffin D, Glusman G, Kasper D, Madan A, Rodrigues S, Fahey J, Wessels MR, and Rubens CE. 2005. Structural and genetic diversity of group B Streptococcus capsular polysaccharides. Infect Immun 73:3096-3103.
2. Rajagopal L, Vo A, Silvestroni A, Rubens CE. 2005. Regulation of purine biosynthesis by a eukaryotic-type kinase in Streptococcus agalactiae. Mol Microbiol 56:1329-1346.
3. Chaffin DO, Mentele LM, and Rubens CE. 2005. Sialylation of group B streptococcal capsular polysaccharide is mediated by cpsK and is required for optimal capsule polymerization and expression. J Bacteriol 187:4615-4626.
4. Tettelin H, Masignani V, Cieslewicz MJ, Donati C, Medini D, Ward NL, Angiuoli SV, Crabtree J, Jones A, Durkin AS, DeBoy RT, Davidsen TM, Mora M, Scarselli M, Maione D, Margarity RI, Peterson JD, Hauser CR, Sundaram JP, Nelson WC, Madupu R, Brinkac LM, Dodson RJ, Rosovitz MJ, Sullivan SA, Daugherty SC, Haft DH, Selengut J, Gwinn ML, Zhou L, Zafar N, Khouri H, Radune D, Dimitrov G, Watkins K, Smith S, Utterback TR, White O, Rubens CE, Grandi G, Madoff LC, Kasper DL, Telford TL, Wessels MR, Rappuoli R, and Fraser CM. 2005. Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: Implications for the microbial "pan-genome." Proc Natl Acad Sci U S A 102:13950-13955.
5. Clancy A, Loar JW, Speziali CD, Oberg M, Heinrichs DE, and Rubens CE. 2006. Evidence for siderophore-dependent iron acquisition in group B streptococcus. Mol Microbiol 59:707-21.
6. Rantanen MK, Lehtio L, Rajagopal L, Rubens CE, and Goldman A. 2006. Crystallization and preliminary crystallographic analysis of two Streptococcus agalactiae proteins, the family II inorganic pyrophosphatase, and the serine/threonine phosphatase. Acta Cryst F62:891-894.
7. Rajagopal L, Vo A, Silvestroni A, Rubens CE. 2006. Regulation of cytotoxin expression by converging eukaryotic-type and two-component signalling mechanisms in Streptococcus agalactiae. Mol Microbiol 62:941-957.
8. Braff MH, Jones AL, Skerrett SJ, Rubens CE. 2007. Staphylococcus aureus exploits cathelicidin antimicrobial peptides produced during early pneumonia to promote staphylokinase-dependent fibrinolysis. J Infect Dis 195:1365-72.
9. Ventura CL, Higdon R, Hohmann L, Martin D, Kolker E, Liggitt HD, Skerrett SJ, Rubens CE. 2008. . Staphylococcus aureus elicits marked alterations in the airway proteome during early pneumonia. Infect Immun, 76(12):5862-5872.
10. Maruvada R, Prasadarao NV, Rubens CE. 2009. Acquisition of factor H by a novel surface protein on group B Streptococcus promotes complement degradation. FASEB J, 23(11) :3967-77.
11. Simmons LE, Rubens CE, Darmstadt GL, Gravett MG. Preventing preterm birth and neonatal mortality: exploring the epidemiology, causes, and interventions. 2010. Semin Perinatol, 34(6):408-15.
12. Adams Waldorf KM, Rubens CE, Gravett MG. 2011. Use of nonhuman primate models to investigate mechanisms of infection-associated preterm birth. Br J Obstet Gynecol, 118(2):136-44.
1. Nizet, V, and Rubens, CE. 2006. Pathogenic mechanisms and virulence factors of group B streptococci. In: Gram-Positive Pathogens, Second Edition, V A Fischetti et al. (eds). American Society for Microbiology, Washington, DC.
2. Jones, A, and Rubens, CE. 2007. Molecular pathogenesis of group B streptococcal infections. In: Molecular Biology of Streptococci, Singh Chhatwal (eds). Horizon Scientific Press, Wymondham, United Kingdom, pp 379-409.