David R. Sherman, PhD
Affiliate Professor of Global Health and TB Program Director, Seattle Biomedical Research Institute
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With about one-third of the world population infected and two million deaths annually, Mycobacterium tuberculosis is unquestionably one of the world's most successful human pathogens. The Sherman laboratory studies the bacterial and host strategies that define tuberculosis disease. He is investigating how TB can remain dormant for years or decades and then activate to cause disease. His laboratory uses the TB vaccine and traits relevant to TB virulence. His studies have important impact on why treatment requires at least six months. He collaborates with Drs. Ramakrishnan, Hawn and Urdahl.
Sherman DR, Voskuil M, Schnappinger D, Liao RP, Harrell MI, Schoolnik GK: Regulation of the M. tuberculosis hypoxic response gene alpha-crystallin. Proc Natl Acad Sci USA, 2001, 98 (13): 7534-7539.
Lewis KN, Liao R, Guinn KM, Smith S, Hickey, MJ, Behr MA, Sherman DR: Deletion of RD1 from M. tuberculosis mimics BCG attenuation. J Inf Dis, 2003, 187: 117-123.
Park HD, Guinn KM, Harrell MI, Liao R, Voskuil MI, Tompa M, Schoolnik GK, Sherman DR: Rv3133c/dosR is a transcription factor that mediates the hypoxic response of M. tuberculosis. Mol Microbiol, 2003, 48(3):833-843.
Guinn KM, Hickey MJ, Mathur SK, Zakel KL, Grotzke JE, Lewinsohn DM, Smith S, Sherman DR: Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis. Mol Microbiol, 2004, 51(2):359-370.
Roberts DM, Liao RP, Wisedenchari G, Hol W, Sherman DR. Two sensor kinases contribute to the hypoxic response of Mycobacterium tuberculosis. J Biol Chem, 2004, 279:23082-7.
Fortune SM, Jaeger A, Chase MR, Sarracino DA, Sassetti CM, Sherman DR, Bloom BR and Rubin EJ. Mutually-dependent secretion of proteins required for mycobacterial virulence. Proc. Natl. Acad. Sci, USA 2005, 102:10676-81.