Danielle Zerr, MD, MPH
Interim Division Chief and Professor of Pediatric Infectious Diseases, Affiliate Investigator at the Fred Hutchinson Cancer Research Center, and the Medical Director of Infection Prevention at Seattle Children’s Hospital
Email: click here
Phone: (206) 987-2653
Dr. Zerr’s research has focused on two main areas: (1) Defining the epidemiology of viral pathogens in healthy children and immunocompromised hosts and (2) describing the epidemiology and defining prevention strategies for healthcare-associated infections. Recent work includes studies investigating the epidemiology of human herpesvirus 6 (HHV-6) in hematopoietic stem cell transplant recipients. This work has involved the application of neuropsychiatric and neuropsychological tools in order to better understand the impact HHV-6 has on the central nervous system in these patients. In addition, Dr. Zerr collaborates with Dr. Weissman in investigating the molecular epidemiology of broad-spectrum beta-lactam resistance in pediatric Enterobacteriaceae infections. Currently, they lead a multi-center surveillance study that will result in integrative analyses of patient characteristics, bacterial phylogenetics, and molecular resistance mechanisms in order to better target prevention strategies. She collaborates with Drs. Corey, Boeckh, Englund, and Weissman.
Brandeis University, B.A., Biology, 1989
Temple University School of Medicine, 1993
Children's Hosptial and Regional Medical Center/University of Washington, 1993-96
Children's Hospital and Regional Medical Center/University of Washington, 1996-99
University of Washington School of Public Health, M.P.H., Epidemiology tract, 1997
Zerr DM, Gupta D, Huang ML, Carter R, Corey L. Effect of Antivirals on Human Herpesvirus 6 Replication in Hematopoietic Stem Cell Transplant Patients. Clin Infect Dis. 2002;34:309-317.
Zerr DM, Yeung L, Obrigewitch RM, Huang ML, Frenkel LM, Corey L. Primary Human Herpesvirus 6 associated with an afebrile seizure in a three-week-old infant. J Med Virol. 2002;66:384-7.
Zerr DM, Garrison M, Marr KA, Christakis DA. A metaanalysis of amphotericin B versus fluconazole for treatment of invasive Candida infections. Journal of Clinical Outcomes Management. 2002;9:191-6.
Byington CL, Zerr DM, Taggart EW, Nguy L, Hillyard DR, Carroll KC, Corey L. Human Herpesvirus-6 Infection in Febrile Infants 90 Days and Younger. Pediatr Infect Dis. 2002; 21:996-9.
Bornemann R, Zerr DM, Heath J, Koehler J, Grandjean M, Duchin J. Salmonella Saintpaul outbreak in a Children’s Hospital. Infect Control Hosp Epidemiol. 2002; 33:671-6.
Allpress AL, Rosenthal GL, Goodrich KM, Lupinetti FM, Zerr DM. Risk Factors for Surgical Site Infections After Pediatric Cardiovascular Surgery. Pediatr Infec Dis. 2004;23:231-4
Zerr DM, Meier AS, Selke SS, Frenkel LM, Huang ML , Wald A, Rhoads MP, Nguy L, Bornemann R, Morrow RA, Corey L. A Population-Based Study of Human Herpesvirus 6 Infection. N Engl J Med. 2005; 352:768-76.
Zerr DM, Corey L, Kim HW, Huang ML, Long N, Boeckh M. Clinical Outcomes of HHV-6 Reactivation During the Course of Hematopoietic Stem Cell Transplantation. Clin Infect Dis. 2005;40:932-40.
Zerr DM, Garrison MM, Allpress AL, Heath J, Christakis DA. Infection Control Policies and Hospital-Associated Infections in Surgical Patients: Variability and Associations in a Multicenter Pediatric Setting. Pediatrics.2005 115: e387-e392.
Christakis DA. Cowan CA. Garrison MM. Molteni R. Marcuse E. Zerr DM. Variation in inpatient diagnostic testing and management of bronchiolitis. Pediatrics 2005;115:878-84,.
Yeung LC, Cunningham, ML, Allpress, AL, Gruss, JS, Ellenbogen, RG, Zerr DM. Surgical site infections following pediatric intracranial surgery for craniofacial malformations: frequency and risk factors. Neurosurgery. 2005;56:733-9.
Zerr DM, Allpress AL, Heath J, Bornemann R, Bennett E. Decreasing Hospital-associated Rotavirus: A Multidisciplinary Hand Hygiene Campaign in a Children’s Hospital. Pediatr Infect Dis J 2005;24:397-403.
Zerr DM, Blume HK, Berg AT, Del Beccaro MA, Gospe SM, Allpress AL, Christakis DA. Nonfebrile Illness Seizures: A Unique Seizure Category. Epilepsia 2005;46:952-55.
Zerr DM. Human Herpesvirus 6: a Clinical Update. Herpes 2006;13:20-4
Zerr DM, Frenkel LM, Huang M-L, Rhoads M, Nguy L, Del Beccaro M, Corey L. PCR Diagnosis of Primary HHV-6 Infection in the Acute Care Setting. J Pediatr 2006;149: 480-485.
Zerr DM. Human Herpesvirus 6 and Central Nervous System Disease in Hematopoietic Cell Transplantation. J Clin Virol 2006;37:S52-6.
Baggett HC, Duchin JS, Shelton W, Zerr DM, Heath J, Ortega-Sanchez IR, Tiwari T. Two Nosocomial Pertussis Outbreaks and Their Associated Costs – King County Washington, 2004. Infect Control Hosp Epidemiol 2007;28:
Rhodes M, Meier A, Zerr DM. Saliva Sharing Behaviors and Early HHV-6 infection. J Infect. In Press 2007.
Kronman MP, Baden HP, Jeffries HE, Heath J, Cohen GA, Zerr DM. An investigation of Aspergillus cardiac surgical site infections in three pediatric patients. Am J Infect Control. In press 2007
Goldin AB, Sawin RS, Garrison MM, Zerr DM, Christakis DA. Aminoglycoside-based triple Antibiotic versus Monotherapy in Children with Ruptured Appendicitis. Pediatrics. In press 2007.
Zerr DM. Effect of human herpesvirus 6 reactivation after hematopoietic stem cell transplantation [Review]. Contagion. 2005;2:352-7.
Zerr DM, Tobin NH, Melvin AJ. Life-Threatening Viral Disease and Its Treatment. In: Fuhrman BP, Zimmerman JJ, eds. Pediatric Critical Care. 3rd ed., St Louis: Mosby Elsevier, 2006.
Heath J, Zerr DM. Infection Acquired in the Nursery: Epidemiology and Control. In: Remington JS, Klein JO, eds. Infectious Diseases of the Fetus and Newborn Infant. 6th ed. Philadelphia: WB Saunders Company. 2006.