Soren Gantt, MD, PhD, MPH
Assistant Professor of Pediatric Infectious Diseases
Email: click here
Phone: (206) 987-1160
Dr. Gantt’s research focuses on the pathogenesis and immunology of human herpesvirus (HHV) infections, including HHV-8, herpes simplex virus (HSV), and cytomegalovirus (CMV). Several studies are ongoing to understand how HHV-8 causes Kaposi sarcoma (KS). KS is the most common cancer in many parts of Africa, including Uganda, where nearly everyone is infected with HHV-8 during childhood. Dr. Gantt, along with Dr. Corey Casper and colleagues at the Fred Hutchinson Cancer Research Center and the Uganda Cancer Institute, is following Ugandan children from birth to characterize clinical manifestations and antiviral immune responses at the time HHV-8 infection is acquired. In collaboration with Dr. Serge Barcy and others, Dr. Gantt is conducting studies to identify the HHV-8-specific immune responses that are dysregulated by HIV infection. In addition, Dr. Gantt has identified that nelfinavir, an HIV protease inhibitor, has previously unrecognized inhibitory activity against HHV-8 and other HHVs. As such, Dr. Gantt is investigating nelfinavir’s novel antiviral mechanism of action in the laboratory, as well as developing clinical trial protocols to evaluate nelfinavir-containing antiretroviral therapy regimens to prevent and treat diseases due to herpesviruses in people co-infected with HIV. Additional studies, in collaboration with Dr. Helen Horton, are underway to determine the role of immune suppressor cell populations in immune maturation and control of HSV and CMV infections during early infancy.
Brown University, Sc.B., Biology, 1993
New York University School of Medicine, Ph.D., 2000, M.D. 2001
Children’s Hospital and Regional Medical Center/University of Washington, 2001-03
Children’s Hospital and Regional Medical Center/University of Washington, 2003-06
Gantt S, Clavijo P, Bai XM, Esko J and Sinnis P (1997) Cell adhesion to a motif shared by the malaria circumsporozoite protein and thrombospondin is mediated by its glycosaminoglycan-binding region and not by CSVTCG. J. Biol. Chem. 272(31): 19205-13.
Gantt S, Myung JM, Briones MRS, Li WD, Corey EJ, Omura S, Nussenzweig V and Sinnis P (1998) Proteosome inhibitors block development of Plasmodium. Antimicrob. Agents Chemother. 42(10): 2731-8.
Kappe S, Bruderer T, Gantt S, Fujioka H, Nussenzweig V and Menard R (1999) Conservation of a gliding motility and cell invasion machinery in apicomplexan parasites. J. Cell Biol. 147(5): 937-44.
Gantt S, Persson C, Abagyan R, Rose K, Birkett AJ and Nussenzweig V (2000) Antibodies against TRAP do not inhibit Plasmodium sporozoite infectivity in vivo. Infect. Immun. 68(6): 3667-3673.
Thathy V, Fujioka H, Gantt S, Nussenzweig R, Nussenzweig V and Menard R (2002) Levels of circumsporozoite protein in the Plasmodium oocyst determine sporozoite morphology. EMBO J. 21(7):1586-96.
Benson C, Gantt S, Zerr DM, Qin X and Abe P (2005) Use of 16S ribosomal DNA polymerase chain reaction to identify Haemophilus influenzae type b as the etiology of pericarditis in an infant. Pediatr. Infect. Dis. J. Mar;24(3):287-8.
Gantt S, Shetty AK, Seidel KD, Matasa K, Musingwini G, Woelk G, Zijenah LS, Katzenstein DA and Frenkel LM (2007) Laboratory Indicators of Mastitis are Not Associated with Elevated HIV-1 DNA or Predictive of HIV-1 RNA Concentrations in Breast Milk. J. Infect. Dis. 196(4):570-6. PMID: 17624843
Gantt S, Carlsson J, Shetty AK, Seidel KD, Qin X, Mutsvangwa J, Musingwini G, Woelk G, Zijenah LS, Katzenstein DA and Frenkel LM (2008) Cytomegalovirus and Epstein-Barr Virus in Breast Milk are Associated with HIV-1 Shedding but Not With Mastitis. AIDS. 22(12):1453-60. PMID: 18614868
Gantt S and Frenkel LM, (2006) Antiviral Therapies, in Gellis and Kagan's Current Pediatric Therapy, 18th Ed., Burg FD, et al., Editors, Saunders.