Kevin Urdahl, MD, PhD
Clinical Assistant Professor of Pediatric Infectious Diseases
Email: click here
Phone: (206) 256-7293
Dr. Urdahlís research is focused on understanding T cell mediated immunity during Mycobacterium tuberculosis (Mtb) infection, including understanding the factors that promote vs. restrict immune protection. His laboratory has recently discovered that antigen-specific natural regulatory T cells expand during early tuberculosis and impair immunity by inhibiting the priming of effector T cells in the lung draining lymph node. Currently, they are studying how these cells are induced, how they affect T cell priming, and also how they impact and are impacted by vaccination. The lab is also studying how protective CD4 T cell responses are maintained throughout chronic infection with Mtb. They have acquired a wide array of reagents and methodologies for tracking Mtb-specific T cell responses, including the use of Mtb-specific MHC class I and class II tetramers, advanced tetramer-based enrichment techniques for tracking rare populations of antigen-specific T cells, and adoptive transfer of CD4+ T cells from Mtb-specific, T cell receptor transgenic mice. They believe that enhanced understanding of the basic biology of the immune response to Mtb will be critical for the development of an effective vaccine strategy. In the future, they plan to confirm and advance the discoveries they have elucidated in the mouse model in human populations immunized against and/or infected with Mtb.
Concordia College, B.S., Chemistry, 1987
University of Minnesota, M.D., Ph.D., 1995
Children's Hospital and Regional Medical Center/University of Washington, 1995-98
Children's Hospital and Regional Medical Center/University of Washington, 1999-2003
Koch MA, Tucker-Heard G, Perdue NR, Killebrew JR, Urdahl KB, Campbell DJ. 2008. T-bet controls regulatory T cell migration and expansion during type-1 inflammatory responses. Submitted.
Scott-Browne JP, Shafiani S, Tucker Heard G, Ishida-Tsubota K, Fontenot JD, Rudensky AY, Bevan MJ, and Urdahl KB. 2007. Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis. J. Exp. Med. 204:2159-69.
Urdahl KB, Liggitt D, and Bevan MJ. 2003. CD8+ T cells accumulate in the lungs of Mycobacterium tuberculosis-infected Kb-/-Db-/- mice, but provide minimal protection. J Immunol, 170(4): 1987-94.
Urdahl KB, Sun JC, and Bevan MJ. 2002. Positive selection of MHC class Ib-restricted CD8+ T cells on hematopoietic cells. Nat Immunol 3:772-79.