Thor Wagner, MD
Assistant Professor of Pediatric Infectious Diseases
Email: click here
Phone: (206) 987-3438
Dr. Wagner’s research is focused on pediatric HIV, which accounts for 15% of all HIV deaths. His primary interest is understanding chronic HIV infection during antiretroviral therapy. Specifically, why doesn't antiretroviral therapy eradicate HIV infection? Is there ongoing viral replication? Is there proliferation of cells with viable proviral HIV? Can we identify the remaining infected cells? Is immune tolerance to HIV a barrier to an HIV cure? Answers to these questions should help design new treatment strategies more likely to cure HIV. Dr. Wagner’s other research interest is improving infectious disease diagnostics in low resource settings. Specifically, he is working to develop a point-of-care diagnostic test for infant HIV. Currently there is no simple test to diagnose infants with HIV, and 50% of HIV-infected children die before they can be diagnosed. To accomplish this, he is utilizing state-of-the-art monoclonal antibody screening technology to optimize the sensitivity of immunoassays to detect HIV antigens.
Princeton University, BA, 1996
Temple University, 2000
Columbia University, Pediatrics, 2000-2003
Seattle Children’s Hospital and University of Washington, Pediatric Infectious Diseases, 2005-2008
Landweber L, Simon PJ, and Wagner T. Ribozyme engineering and early evolution. BioSciences, 1998; 48:94-103.
Wagner T, Soong G, Sokol S, Saiman L, and Prince A. Effects of azithromycin on clinical isolates of Pseudomonas aeruginosa from cystic fibrosis patients. Chest, 2005; 128:912-919.
Wagner, T. and Burns, J. Anti-inflammatory Properties of Macrolides. Pediatric Infectious Disease Journal 2007; 26: 75-76.
Wagner, T. and Frenkel, L. Clinical Significance of HIV-1 Drug Resistance Mutations. J. of Lab. Medicine 2006; 37: 554-561.
Wagner TA, and Frenkel LM. Potential limitation of CCR5 antagonists: drug resistance more often linked to CXCR4-utilizing than to CCR5-utilizing HIV-1. AIDS 2008; 22:2393-2395. PMCID: PMC2585823.
Lin CH, Sloan DD, Dang CH, Wagner T, Cabrera AJ, Tobin NH, Frenkel LM, and Jerome KR. 2009. Assessment of mitochondrial toxicity by analysis of mitochondrial protein expression in mononuclear cells. Cytometry B Clin Cytom 76:181-190.
Wagner TA, Tobin NH, McKernan JL, Xu M, Melvin AJ, Mohan KM, Learn GH, Mullins JI, and Frenkel LM. Increased mutations in Env and Pol suggest greater HIV-1 replication in sputum-derived viruses compared with blood-derived viruses. AIDS 2009; 23:923-928. PMCID: PMC2677633.
Jourdain, G, Wagner, T., Ngo-Giang-Huong, N., Sirungsi, W., Klinbuayaem, V., Fregonese, F., Nantasen, I., Techpornroong, M., Halue, G., Nilmanat , A., Wittayapraparat , P., Chalermpolprapa , V., Pathipvanich , P., Yuthavisuthi , P., Frenkel, L., and Lallemant, M. for the Program for HIV Prevention and Treatment (PHPT) Study Group. Association between Detection of HIV-1 DNA Resistance Mutations by a Sensitive Assay at Initiation of Antiretroviral Therapy and Virologic Failure. Clinical Infectious Diseases 2010; 50: 1397-1404. PMCID: PMC2856716.
Quan, P-L., Wagner, T., Briese, T., Kapur, R., Torgerson, T., Hornig, M., Firth, C., Palacios, G., Baisre-De-Leon, A., Hutchison, S., Egholm, M., Goldman, J., Hans D Ochs, H., Lipkin, W. Astroviral encephalitis in a 15 year-old boy with X-linked agammaglobulinemia. Emerging Infectious Diseases 2010; 16; 918-925.
Wagner, T., Cress, K., Beck, I., Techapornroong, M., Wittayapraparat, P., Tunsuphasawasdikul, S., Jourdain, G., Ngo-Giang-Huong, N., S., Lallemant, M., and Frenkel, L. Detection of HIV-1 Drug Resistance in Women Following Administration of a Single Dose of Nevirapine: Comparison of Plasma RNA to Cellular DNA by Consensus Sequencing and by Oligonucleotide Ligation Assay. Journal of Clinical Microbiology 2010; 48: 1555-1561. PMCID: PMC2863880.
Wagner, T. and Frenkel, L. Antiretroviral Treatment for HIV-Infected Infants Exposed to Nevirapine (letter). JAMA 2010; 304; 2589.
Beck IA, Jang M, McKernan J, Bull M, Wagner TA, Huang S, Song LY, Nachman S, Krogstad P, Eshleman S, Wiznia A, Frenkel LM. Monitoring of HIV-1 DNA Load and Drug Resistance in Peripheral Blood Mononuclear Cells during Suppressive Antiretroviral Therapy does not Predict Virologic Failure. AIDS Research and Human Retrovirology, Epub Nov 2011.
Wagner, TA., Gravett, C., Healy, S., Soma, V., Patterson, J., Gravett, M., Rubens, C. Emerging Biomarkers for the Diagnosis of Severe Neonatal Infections Applicable to Low Resource Settings. Journal of Global Health 2011 (in press).
Wagner, TA. Gravett, C., Gravett, M., and Rubens, C. A global health opportunity: the potential of multiplexed diagnostics in low resource settings (viewpoint). Journal of Global Health, 2011 (in press)
Wagner, TA. and Frenkel, LM. Yet another reason to treat HIV (editorial). Clinical Infectious Diseases (in press).