Angela J. P. Campbell, MD, MPH
Assistant Professor of Pediatric Infectious Diseases
Email: click here
Phone: (206) 667-6023
Dr. Campbellís research focuses on factors that influence the acquisition of respiratory virus infection and disease progression among immunocompromised children and adults, with the goal to facilitate new diagnostic, preventive, and treatment strategies for respiratory virus infections. She was recently a co-investigator for a large prospective study of respiratory virus infections in hematopoietic stem cell transplant recipients, with an emphasis on parainfluenza virus (PIV) infections. PIVs are ubiquitous respiratory viruses that are second only to respiratory syncytial virus (RSV) as important viral causes of lower respiratory infection in children and immunocompromised patients. Unlike RSV, there are no specific antiviral therapies to prevent or treat PIVs. These viruses are important sources of morbidity and mortality in adult and pediatric immunocompromised patients, especially hematopoietic cell transplant (HCT) recipients. Among HCT recipients, PIVs are the most common serious respiratory viruses, with high rates of pneumonia and increased risk of mortality even with upper respiratory tract disease alone. The spectrum of PIV infection can range from asymptomatic infection to pneumonia and death in the HCT population. Prolonged viral shedding, increased risk of long-term airflow obstruction, and high rates of nosocomial transmission accompany PIV infection in HCT recipients. Her studies will be important to document rates of asymptomatic PIV infection in a large cohort of HCT recipients, to determine if asymptomatic infection leads to progression of respiratory disease, to clearly define the presence of persistent subclinical shedding, and to analyze whether humoral immunity is protective against symptomatic infection or disease progression. She is also interested in developing a method by which patients can collect their own respiratory samples for respiratory virus testing and was the principal investigator for a recent study of self-collected swabs from patients with cystic fibrosis, as well as an ongoing study of self-collected swabs from hematopoietic stem cell transplant recipients.
Augustana College, B.A., Biology, 1993
Vanderbilt University, 1995-1999
University of Washington/Children's Hospital and Regional Medical Center, 2000-2002
University of Washington/Children's Hospital and Regional Medical Center, 1999-2002
Vanderbilt University, Graduate study, Microbiology and Immunology, 1993-1995
Centers for Disease Control and Prevention, Epidemic Intelligence Service Officer, 2002-2004
Vu, Debie, Peck AJ, Nichols WG, Varley C, Englund JA, Corey L, Boeckh M. Safety and Tolerability of Oseltamivir Prophylaxis in Hematopoietic Stem Cell Transplantation Recipients: A Retrospective Case-Control Study (*contributed equally). Clin Infect Dis, 2007;45:187-93. Epub 2007 June 5.
Peck AJ, Englund JA, Kuypers J, Corey L, Morrow R, Cent A, Boeckh M. Respiratory Virus Infection among Hematopoietic Cell Transplantation Recipients: Evidence for Asymptomatic Parainfluenza Virus Infection. Blood, 2007;110:1681-88. Epub 2007 May 14.
Gutman JA, Peck AJ, Kuypers J, Boeckh M. Rhinovirus as a cause of fatal lower respiratory tract infection in adult stem cell transplantation patients: A report of two cases. Bone Marrow Transplant, 2007:40:809-11. Epub 2007 Aug 20.
Nichols WG, Peck Campbell AJ, Boeckh, M. Respiratory Viruses Other than Influenza Virus: Impact and Therapeutic Advances. Clin Micro Rev, in press.
Peck AJ, Newbern EC, Feikin DR, Isakbaeva ET, Park BJ, Fehr J, et al (2004). Lack of SARS Transmission and US SARS Case-Patient. Emerg Infect Dis 10(2):217-224.
Park BJ, Peck AJ, Kuehnert M, Newbern EC, Smelser C, Jernigan D, et al (2004). Lack of SARS Transmission among Healthcare Workers, United States. Emerg Infect Dis 10(2):244-248.
Isakbaeva ET, Khetsuriani N, Beard RS, Peck A, Erdman D, Monroe SS, et al (2004). SARS-Associated Coronavirus Transmission, United States. Emerg Infect Dis 10(2):225-231.
Peck AJ, Corey L, and Boeckh M (2004). Pretransplantation Respiratory Syncytial Virus Infection: Impact of a Strategy to Delay Transplantation. Clin Infect Dis 39(5):673-680.
Peck AJ, Holman RC, Curns AT, Lingappa JR, Cheek JE, Singleton RJ, et al (2005). Lower Respiratory Tract Infections among American Indian and Alaska Native Children and the General Population of U.S. Children. Pediatr Infect Dis J 24(4):342-51.
Hicks LA, Shepard CW, Britz PH, Erdman DD, Fischer M, Flannery BL, Peck AJ, et al (2006). Two outbreaks of severe respiratory disease in nursing homes associated with rhinovirus. J Am Geriatr Soc 54:284-89.
Vu, Debie,* Peck AJ,* Nichols WG, Varley C, Englund JA, Corey L, Boeckh M. Safety and Tolerability of Oseltamivir Prophylaxis in Hematopoietic Stem Cell Transplantation Recipients: A Retrospective Case-Control Study (*contributed equally). Clin Infect Dis, in press.
Peck AJ and Bresee JS. Viral Gastroenteritis. In: Oskiís Pediatrics: Principles and Practice, 4th Edition. McMillan, et al., editors, Lippincott Williams & Wilkins, 2006.