• Faculty Member Photo
  • Janet A. Englund, MD
    Professor of Pediatric Infectious Diseases
    Email: click here
    Phone: (206) 987-2073

Dr. Englund’s research interests include the study of vaccine-preventable diseases and viral respiratory diseases in young children and immunocompromised hosts, as well as the evaluation of antiviral therapy for the prevention and treatment of viral diseases. As a Clinical Associate at Fred Hutchinson Cancer Research Center, she is actively involved in transplant-related protocols in the prevention and treatment of disease in the immunocompromised host. She also studies the development of antiviral resistance and novel methods of antiviral therapy for various respiratory viruses. Dr. Englund and her research team are involved in research studies of new respiratory vaccines, partnering with Dr. Ruth Karron/Johns Hopkins University and Dr. Peter Collins/NIAID/NIH, to study live attenuated vaccines against RSV, parainfluenza virus, and human metapneumovirus. Her research group is also involved in new methods of enhanced diagnosis of respiratory diseases in collaboration with Dr. Paul Yager, Dept. of Bioengineering, UW. She is currently involved with the study of maternal immunization with influenza virus vaccines in Nepal in a large placebo-controlled clinical trial directed by Drs. Mark Steinhoff, Cincinnati Children’s Hospital, and James Tielsch/Joanne Katz at Johns Hopkins University School of Medicine. Dr. Englund is also interested in vaccine policy and implementation and is actively involved in vaccine issues with the Pediatric Infectious Diseases Society, the American Academy of Pediatrics, the ACIP (American Committee on Immunization Practices) and the WHO (World Health Organization).

Undergraduate
University of Michigan, B.S., Microbiology, 1976

Medical School
University of Michigan, 1980

Residency
University of Minnesota, 1980-83

Fellowship
University of Minnesota, 1984-87

Selected Recent Publications

Influenza
Tsuang WM, Bailar JC, Englund JA. Influenza-like symptoms in the college dormitory environment: a survey taken during the 1999-2000 influenza season. J Environ Health. 2004 Apr;66(8):39-42.
Englund JA, Walter EB, Fairchok MP, Monto AS, Neuzil KM: A comparison of 2 influenza vaccine schedules in 6- to 23-month-old children. Pediatrics 2005;115:1039-1047.
Englund JA, Walter EB, Gbadebo A, Monto AS, Zhu Y, Neuzil KM: Immunization with trivalent inactivated influenza vaccine in partially immunized toddlers. Pediatrics 2006;118:e579-585.
King JC, Jr., Stoddard JJ, Gaglani MJ, Moore KA, Magder L, McClure E, Rubin JD, Englund JA, Neuzil K: Effectiveness of school-based influenza vaccination. N Engl J Med 2006;355:2523-2532.
Walter EB, Neuzil KM, Zhu Y, Fairchok MP, Gagliano ME, Monto AS, Englund JA: Influenza vaccine immunogenicity in 6- to 23-month-old children: are identical antigens necessary for priming? Pediatrics 2006;118:e570-578.
Vu D, Peck AJ, Nichols WG, Varley C, Englund JA, Corey L, Boeckh M. Safety and tolerability of oseltamivir prophlylaxis in hematopoietic cell transplantation recipients: A retrospective case-control study. Clin Infect Dis 2007, 45:187-93.
Tasian SK, Park JR, Martin ET, Englund JA. Influenza-associated morbidity in children with cancer. Ped Cancer, 2008 (Jan. 31: Epub).
Zerr DM, Englund JA, Robertson AS, Marcuse EK, Garrison MM, Christakis DA. Hospital-based influenza vaccination of children: An opportunity to prevent subsequent hospitalization. Pediatrics 2008;121:345-8


RSV
Martin ET, Kuypers J, Heugel J, Englund JA. Clinical disease and viral load in children infected with respiratory syncytial virus or human metapneumovirus. Diagn Micro Infect Dis 2008 (in press).
DeVincenzo JP, Hall CB, Kimberlin DW, Sanchez PJ, Rodriguez WJ, Jantausch BA, Corey L, Kahn JS, Englund JA, Suzich JA, Palmer-Hill FJ, Branco L, Johnson S, Patel NK, Piazza FM. Surveillance of clinical isolates of respiratory syncytial virus for palivizumab (Synagis)-resistant mutants. J Infect Dis 2004;190(5):975-978.
Randolph AG, Reder L, Englund JA: Risk of bacterial infection in previously healthy respiratory syncytial virus-infected young children admitted to the intensive care unit. Pediatr Infect Dis J 2004;23:990-994.
Boeckh M, Englund J, Li Y, Miller C, Cross A, Fernandez H, Kuypers J, Kim H, Gnann J, Whitley R: Randomized controlled multicenter trial of aerosolized ribavirin for respiratory syncytial virus upper respiratory tract infection in hematopoietic cell transplant recipients. Clin Infect Dis 2007;44:245-249.

New Respiratory Viruses: Diagnosis and Epidemiology
Kunz A, Englund JA, Kuypers J, Maranich A, Fairchok MP. Detection of Multiple Respiratory Viruses by Real-Time Polymerase Chain Reaction in Infants Attending an Outpatient Clinic. Eur J Clin Micro Infect Dis 2008; 27 (June 14). (Epub ahead of print).
Stempel H, Martin ET, Kuypers J, Englund JA, Zerr DM. Multiple viral respiratory pathogens in children with bronchiolitis. Acta Paediatrica, 2008; Sep 9 (Epub ahead of print) PMID: 18785966
Boeckh M, Erard V, Zerr D, Englund J: Emerging viral infections after hematopoietic cell transplantation. Pediatr Transplant 9 Suppl 2005;7:48-54.
Englund JA, Boeckh M, Kuypers J, Nichols WG, Hackman RC, Morrow RA, Fredricks DN, Corey L: Fatal human metapneumovirus infection in stem-cell transplant recipients. Ann Intern Med 2006;144:344-349.
Heugel J, Kuypers J, Martin E, Englund JA. Coronavirus-associated pneumonia in previously healthy children. Pediatr Inf Dis J 2007, 26:753-5.
Kuypers J, Martin ET, Heugel J, Wright N, Morrow R, Englund JA: Clinical disease in children associated with newly described coronavirus subtypes. Pediatrics 2007;119:e70-76.
Peck A, Englund JA, Kuypers J, Guthrie K, Corey L, Morrow R, Cent A, Boeckh M. Respiratory Virus Infection among Hematopoietic Cell Transplantation Recipients: Evidence for Asymptomatic Parainfluenza Virus Infection. Blood 2007,110:1681-8.

Pertussis
Forsyth KD, Campins-Marti M, Caro J, Cherry JD, Greenberg D, Guiso N, Heininger U, Schellekens J, Tan T, von Konig CH, Plotkin S (Global Pertussis Initiative): New pertussis vaccination strategies beyond infancy: recommendations by the global pertussis initiative. Clin Infect Dis 2004;39:1802-1809.
Wendelboe AM, Van Rie A, Salmaso S, Englund JA: Duration of immunity against pertussis after natural infection or vaccination. Pediatr Infect Dis J 2005;24:S58-61.
Tan T, Halperin S, Cherry JD, Edwards K, Englund JA, Glezen P, Greenberg D, Rothstein E, Skowronski D. Pertussis immunization in the Global Pertussis Initative North American region: recommended strategies and implementation considerations. Pediatric Inf Dis J 2005;24 (Suppl);S83-7.
Qin X, Galanakis E, Martin ET, Englund JA. Multi-target Polymerase Chain Reaction for Diagnosis of Pertussis and Its Clinical Implications. J Clin Microbiol 2007;45:506-11
Galanakis E, Englund JA, Abe P, Qin X. Antimicrobial susceptibility of Bordetella pertussis isolates in the state of Washington. Int J Antimicrob Agents 2007;29:609-11

Maternal Immunization
Santosham M, Englund JA, McInnes P, Croll J, Thompson CM, Croll L, Glezen WP, Siber GR. Safety and antibody persistence following Haemophilus influenzae type b conjugate or pneumococcal polysaccharide vaccines given before pregnancy in women of childbearing age and their infants. Pediatr Infect Dis J. 2001 Oct;20(10):931-940.
Munoz FM, Englund JA, Cheesman C, Maccato M, Pinell P, Nahm MH, Mason EO, Kozinetz CA, Thompson R, Glezen WP. Maternal immunization with pneumococcal polysaccharide vaccine in the third trimester of gestation. Vaccine. 2002;20:826-837
Englund JA. Maternal immunization with inactivated influenza vaccine: Rationale and Experience. Vaccine (2003).
Englund JA and Glezen WP. Maternal immunization with Hemophilus influenza type b vaccines in different populations. Vaccine 2003;21: 3455-3459.
Van Rie A, Wendelboe AM, Englund JA: Role of maternal pertussis antibodies in infants. Pediatr Infect Dis J 2005;24:S62-65.

Editorials
Englund J. In search of a vaccine for respiratory syncytial virus: the Saga continues. Editorial, J Infect Dis 2005, 191:1036-9.
Neuzil K, Englund JA. Influenza vaccine for young children: Two doses are better than one. J Pediatr 2006 Dec;149:737-8.


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