Robert Coombs, PhD
Professor of Laboratory Medicine
Email: click here
The focus of Dr. Coombs’ research activity is on the pathogenesis of HIV-1 and the quantification of viral load in the setting of therapeutic clinical trials involving both adult and pediatric HIV-1 infected subjects. Of particular interest is validation of HIV-1 DNA and unintegrated episomal 2-LTR viral DNA as markers of infectivity when viral RNA levels are suppressed in the plasma with effective antiretroviral therapy. Research investigation to elucidate the mechanisms of shedding of HIV-1 in the male and female genital tracts and the regulation of HIV-1 shedding by genital tract inflammation is ongoing in collaboration with Drs. Corey, Frenkel, and McElrath.