David M. Koelle, MD
Professor of Medicine, Global Health Medicine, and Laboratory Medicine
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Lab interests include the human T-cell response to viral infections and the creation of effective vaccines including murine studies and human clinical trials. We specialize in high-definition, high-throughput molecular dissection of the human CD8 and CD4 T-cell responses to large-genome viruses such as HSV-1, HSV-2, HHV-8, and vaccinia using a suite of genetic tools. Candidate vaccine antigens are being tested in animal challenge models with measurement of immunogenicity, pathogenesis and efficacy. Other projects include study of the T-cell response to a small oncogenic polyomavirus, use of vaccinia as an HIV vector, and sequencing studies of wild-type HSV strains for strain-tracking molecular epidemiology and antiviral drug resistance research. He has supervised adult and pediatric ID fellows and graduate students and collaborates with UW and FHCRC faculty in several departments.