Faculty (faculty in italics accept students in their laboratories)

Michael J. Bevan, T-lymphocyte differentiation in the thymus and positive selection of the receptor repertoire; the T-cell response to viral and bacterial infection; antigen processing and presentation.

Edward A. Clark, Regulation of B-cell and dendritic cell survival and death; molecules regulating germinal center formation.

Andrew G. Farr, Thymic stromal cell development; definition of nonlymphoid elements in the thymic environment.

Pamela J. Fink, The induction of tolerance among mature T cells in a T-cell receptor transgenic mouse model system; reverse signaling through Fas L as a positive regulator of T-cell proliferation and maturation.

Michael Gale, Jr., Virus-host interactions that control innate defenses and immunity to infection; genetic and functional analysis of the innate immune antiviral response; interferon biology; immune control of the replication and pathogenesis of hepatitis C virus, West Nile virus, and human immunodeficiency virus.

Joan M. Goverman, Autoimmune disease and mechanisms of acquiring immunological tolerance to self antigens.

Philip Greenberg, T-cell responses to infectious viruses and transformed cancer cells; immunobiology and pathogenesis of HIV; modification of T cells for adoptive therapy by gene insertion; signal transduction by cytokine receptors.

Lynn Hajjar, Innate immune recognition of microbial pathogens by Toll-like receptors (TLRs).

Murali-Krishna Kaja, Antiviral immunity; lymphoid homeostasis and aging; interphase between innate and adaptive immunity; improvement of vaccination strategies.

Nancy Maizels, Immunoglobulin gene class switch recombination and somatic hypermutation in activated B cells; mammalian DNA repair, genomic instability, and cancer.

Alexander Y. Rudensky, Development of CD4 T cells in the thymus; antigen processing and presentation by MHC class II molecules.

Daniel B. Stetson, Nucleic acid detection in host defense and autoimmunity; biology of antiviral responses.

Amy Weinmann, Mechanisms of transcriptional regulation in the immune system; cell-type specificity of transcription factors.

Christopher B. Wilson, Epigenetic regulation of T cell development and function; host defense to viral and intracellular bacterial pathogens; innate immune recognition.

Adjunct and Affiliate Faculty

Alan A. Aderem, Mechanisms of phagocytosis and cell movement; macrophage development and differentiation.

Daniel Campbell, Lymphocyte homing and function; regulatory T cell localization; effector lymphocyte differentiation; tolerance in transplantation and autoimmunity.

Keith Elkon, Mechanisms of autoimmune disease; role of apoptosis in tolerance and autoimmunity.

Jessica Hamerman, Macrophage and dendritic cell activation, macrophage and dendritic cell responses to infection with bacteria and viruses, regulation of inflammatory responses.

Leroy Hood, Molecular recognition, autoimmune disease, tolerance, and the differentiation of T cells.

William Kwok, Uses of HLA class II tetramers to probe CD4+ T cell responses in various disease settings in humans.

Michael Lagunoff, Molecular virology of Kaposi's Sarcoma-associated herpesvirus (KSHV or HHV-8) and host cell responses to infection of B-cells and endothelial cells.

Yvette Latchman, Costimulatory pathways:role in autoimmunity and tumor responses

Gerald T. Nepom, Molecular and genetic mechanisms contributing to triggering autoimmune disorders, in particular, the role of HLA class II genes.

Lalita Ramakrishnan, Bacterial pathogenesis; bacterial persistence; granuloma; host resistance to tuberculosis.

David Rawlings, Dysregulated B cell development and signaling leading to immunodeficiency, autoimmunity, or lymphoid malignancies; Gene therapy for primary immunodeficiency.

Helena Reijonen, Characterization of autoantigen specific T cell responses, mechanisms of the MHC class II mediated predisposition and protection in autoimmune diabetes.

Andrew Scharenberg, Signal transduction mechanisms and cation channel function in the immune system.

Roland K. Strong, Structural immunology: the analysis of the functions of proteins and protein/receptor complexes mediating immune responses through the study of their structures by molecular biology, solution biochemistry and x-ray crystallography.

Steve Ziegler, Genetic and molecular analysis of immune system regulation; mechanisms of cytokine-mediated signal transduction; use of mouse mutants to uncover novel regulatory pathways.

Updated 7/08