Alan A. Aderem, PhD
Affiliate Professor, Immunology and Medicine
Director, Institute for Systems Biology

The Institute for Systems Biology 
1441 North 34th Street
Seattle, WA 98103-8904
Phone: (206) 732-1200
Fax: (206) 732-1299
Email: aderem@systemsbiology.org

Aderem Lab

Dr. Aderem received his Ph.D. in 1979 from the University of Cape Town, South Africa, and joined the faculty of the Rockefeller University, New York, in 1982. In 1991 he was appointed head of the Laboratory of Signal Transduction at the Rockefeller University.
He joined the Department of Immunology at the University of Washington in 1996, and co-founded the Institute for Systems Biology in 2000 where he serves as director.

Current research interests: Our focus is on the innate immune system; how it recognizes and formulates responses to infectious agents, and how it instructs the adaptive immune system to provide long-lived immunity to the pathogen. Our initial studies defined how pattern recognition receptors, in particular the Toll-like receptors, identify bacteria: in essence, how the immune cell reads the molecular bar-code of the microbe and thereby precisely defines the nature of the threat. This precise recognition triggers a specific, highly regulated, response to the pathogen by the host. Our current focus is the molecular definition of these responses. To do so we are using the tools of systems biology to develop predictive models of the immune and inflammatory responses. We are also using nanotechnology to build devices with sufficient sensitivity to allow multi-parameter analysis of single cells. The long-term goals are predictive and preventive medicine.

Students currently training in the Aderem Lab: Sarah Warren

Representative publications:

Underhill, D.M., A. Ozinsky, A.M. Hajjar, A. Stevens, C.B. Wilson, M. Bassetti, A. Aderem. 1999. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401:811-815.

Ozinsky A., Underhill D.M., Fontenot J., Hajjar A., Smith K.D., Wilson C. B., Schroeder L., and Aderem A. 2000. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. Proc. Natl. Acad. Sci. U.S.A. 97: 13766-13771.

Hayashi, F., D.M. Underhill, A. Ozinsky, K.D. Smith, E.C. Yi, D.R. Goodlett, J.K. Eng, and A. Aderem. 2001. The innate immune response to bacterial flagellin is mediated by Toll-like receptor-5. Nature 410(6832):1099-1103.

Aderem A., and L. Hood L. 2001. Immunology in the post-genomic era. Nat. Immunol. 2:373-5. Smith KD, Andersen-Nissen E, Hayashi F, Strobe K, Bergman MA, Barrett SL, Cookson BT, Aderem A. 2003. Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility. Nat Immunol. (12):1247-53.

Hawn TR, Verbon A, Lettinga KD, Zhao LP, Li SS, Laws RJ, Skerrett SJ, Beutler B, Schroeder L, Nachman A, Ozinsky A, Smith KD, Aderem A. 2003. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J. Exp. Med. 198:1563-72.

Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S, and Aderem A. 2004. Lipocalin 2 mediates a novel innate immune response to bacterial infection by sequestrating iron. Nature. 16:917:21.

Andersen-Nissen E, Smith KD, Strobe KL, Barrett SL, Cookson BT, Logan SM, Aderem A. 2005. Evasion of Toll-like receptor 5 by flagellated bacteria. Proc Natl Acad Sci USA. 102:9247-52.

Hawn TR, Wu H, Grossman JM, Hahn BH, Tsao BP, Aderem A. 2005. A TLR5 stop codon polymorphism is associated with resistance to systemic lupus erythematosus. Proc Natl Acad Sci USA. 102: 10593-10597.

Roach JC, Glusman G, Rowen L, Kaur A, Purcell MK, Smith KD, Hood LE, Aderem A. 2005. The evolution of vertebrate Toll-like receptors. Proc Natl Acad Sci USA. 102:9577-82.

Aderem A. 2005. Systems biology: its practice and challenges. Cell. 121:511-13.

Gilchrist M, Thorsson V, Li B, Rust AG, Korb M, Kennedy K, Hai T, Bolouri H, Aderem A. 2006. Systems Biology Approaches Identify ATF3 as a Negative Regulator of Innate Immunity. Nature. 441:173-8.

Miao, EA, CM Alpuche-Aranda, M Dors, AE Clark, MW Bader, SI Miller, and A Aderem. 2006. Cytoplasmic flagellin activates Caspase 1 and IL-1β secretion through Ipaf. Nature Immunology. 7:569-75.

Andersen-Nissen E, Smith KD, Bonneau R, Strong RK, Aderem A. 2007. A conserved surface on Toll-like receptor 5 recognized bacterial flagellin. J Exp Med. 204:393-403.

Roach JC, Smith KD, Strobe KL, Nissen SM, Haudenschild CD, Zhou D, Vasicek TJ, Held GA, Stolovitzky GA, Hood LE, Aderem A. 2007. Transcription factor expression in lipopolysaccharide-activated peripheral-blood-derived mononuclear cells. Proc Natl Acad Sci U S A. 104:16245-50.

Miao EA, Ernst RK, Dors M, Mao DP, Aderem A. 2008. Pseudomonas aeruginosa activates caspase 1 through Ipaf. Proc Natl Acad Sci U S A. 105:2562-7.

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Updated July 2008