Institute for Systems Biology
1441 North 34th Street
Seattle, WA 98103-8904
Phone: (206) 732-1200
Fax: (206) 732-1299
E-mail: hood@systemsbiology.org

Hood Lab

Dr. Hood graduated from the California Institute of Technology (Caltech) with a BS in biology and received his M.D. from the Johns Hopkins Medical School. He returned to Caltech, completing his Ph.D. in 1968. A member of the National Academy of Sciences, the American Philosophical Society, the American Academy of Arts and Sciences, and the Institute of Medicine. Dr. Hood has received numerous awards, including the 2002 Kyoto Prize for Advanced Technology, the 1987 Lasker Basic Medical Sciences Research Award for studies of immune diversity, the 2003 Lemelson-MIT Prize for invention and innovation, and the 2004 Biotechnology Heritage Award. Dr. Hood joined the University of Washington in 1992 as the William Gates III Professor of Biomedical Sciences and the founding Chairman of the Department of Molecular Biotechnology. He left the University of Washington in 2000 to co-found and become the President of the Institute for Systems Biology.

Dr. Hood's projects center on cancer biology (prostate, ovarian, breast and liver cancers), systems approach to prion disease in mice and prostate cancer, new strategies for obtaining blood biomarkers, and a systems approach to the differentiation of hematopoietic stem cells. He is also interested type I diabetes. Finally, Dr. Hood's laboratory is developing new tools and applications for genomics (large-scale DNA sequencing), computation (various approaches to delineating and engineering biological networks), and nanotechnology measurements of blood proteins.

Recent publications:

Davidson, E.H., D.R. McClay, and L. Hood (2003) Regulatory Gene Networks and the Properties of the Developmental Process. Proceedings of the National Academy of Sciences USA, 100:1475-1480.

Heath, J.R., M.E. Phelps and L. Hood (2003) NanoSystems Biology. Journal of Molecular Imaging and Biology 5:312-325.

Weston, A.D. and L. Hood (2004) Systems Biology, Proteomics, and the Future of Health Care: Toward Predictive, Preventative, and Personalized Medicine. Journal of Proteome Research 3:179-196.

Weston, A.D., N.S. Baliga, R. Bonneau and L. Hood (2004) Systems Approaches Applied to the Study of Saccharomyces cerevisiae and Halobacterium sp. Proceedings of the Cold Spring Harbor Symposium on Quantitative Biology: The Genome of Homo Sapiens. Volume LXVIII. Cold Spring Habor Press.

Lin, B., J.T. White, W. Lu, T. Xie, A.G. Utleg, X. Yan, E.C. Yi, P. Shannon, I. Khrebtukova, P.H. Lange, D.R. Goodlett, D. Zhou, T.J. Vasicek and L. Hood (2005) Evidence for the Presence of Disease-Perturbed Networks in Prostate Cancer Cells by Genomic and Proteomic Analyses: A Systems Approach to Disease. Cancer Research 65:3081-3091.

Bunimovich, Y.L., G. Ge, K.C. Beverly, R.S. Ries, L. Hood and J.R. Heath (2004) Electrochemically Programmed,Spatially Selective Biofunctionalization of the Silicon Wires. Langmuir 20:10630-10638.

Bonneau, R., D.J. Reiss, P. Shannon, M. Facciotti, L. Hood, N.S. Baliga and V. Thorsson (2006) The Inferelator: An Algorithm for Learning Parsimonious Regulatory Networks from Systems-Biology Data Sets de novo. Genome Biology 7:R36.

Foltz, G., G-Y Ryu, J-G Yoon, T. Nelson, J. Fahey, A. Frakes, H. Lee, L. Field, K. Zander, Z. Sibenaller, T.C. Ryken, R. Vibhakar, L. Hood and A. Madan (2006) Genome-Wide Analysis of Epigenetic Silencing Identifies BEX1 and BEX2 as Candidate Tumor Suppressor Genes in Malignant Glioma. Cancer Research 66:1-10.

Glusman, G., S. Qin, M. Raafat El-Gewely, A.F. Siegel, J.C. Roach, L. Hood and A.F.A. Smit (2006) A Third Approach to Gene Prediction Suggests Thousands of Additional Human Transcribed Regions. PLoS Computational Biology 2:e18.

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Updated August 2006