Student Publications

Alaniz RC, Sandall S, Thomas EK and CB Wilson. 2004. Increased Dendritic Cell Numbers Impair Protective Immunity to Intracellular Bacteria Despite Augmenting Antigen-Specific CD8+ T Lymphocyte Responses. J Immunol, 172: 3725-3735.

Alaniz RC, Thomas SA, Perez-Melgosa M, Mueller K, Farr AG, Palmiter RD and CB Wilson. 1999. Dopamine b-hydroxylase deficiency impairs cellular immunity. Proc. Natl. Acad. Sci. USA, Mar 2;96(5):2274-8.

Andersen-Nissen E, Smith KD, Bonneau R, Strong RK, Aderem A. A conserved surface on Toll-like receptor 5 recognizes bacterial flagelin. J Exp Med. 2007 Feb 19, 204(2):393-403.

Smith KD, Andersen-Nissen E, Hayashi F, Strobe K, Bergman MA, Barrett SL, Cookson BT and A Aderem. 2003. Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility. Nature Immunol (12):1247-53.

Peckham D, Andersen-Nissen E, Finkelman FD, Stunz LL and RF Ashman. 2001. Difference in apoptosis induction between surface IgD and IgM. Int Immunol. Mar; 13(3):285-95.

Astrakhan A, Omori M, Nguyen T, Becker-Herman S, Iseki M, Aye T, Hudkins K, Dooley J, Farr A, Alpers CE, Ziegler SF, Rawlings DJ. 2007. Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development. Nature Immunol. (Advance Online Publication)

Wong, P., Barton GM, Forbush KA and AY Rudensky. 2001. Tuning of T cell reactivity by self-peptide/MHC ligands. J.Exp. Med., 193:1179-1188.

Barton GM and AY Rudensky. 1999. Evaluating peptide repertoires within the context of thymocyte development. Seminars in Immunology, 11:417-422.

Barton, GM and AY Rudensky. 1999. Requirement for Diverse, Low-Abundance Peptides in Positive Selection of T Cells. Science 283:67-70.

Barton GM and AY Rudensky. 1998. An altered invariant chain protein with an antigenic peptide in place of CLIP forms SDS-stable complexes with class II ab dimers and facilitates highly efficient peptide loading. Intl. Immunol. 10:1159-1165.

Barton GM, Beers C, DeRoos P, Eastman SE, Gomez ME, Forbush KA and AY Rudensky. 2000. Positive selection of self-reactive T cells by specific peptide-MHC class II complexes. Submitted for publication.

Beers C, Honey K, Finks, Fink S, Forbush K, Rudensky A. 2003. Differential regulation of cathepsin S and cathepsin L in interferon gamma-treated macrophages. J Exp Med. 197(2):169-79.

Honey K, Duff M, Beers C, Maric M, Cresswell P and AY Rudensky. 2001. Cathepsin S regulates expression of cathepsin L and turnover of GILT in B lymphocytes. J. Biol. Chem. 276:22573-8.

Honey K, BenlaghaK, Beers C, Forbush K, Teyton L, Kleijmeer MJ, Rudensky AY, Bendelac A. 2002. Thymocyte expression of cathepsin L is essential for NKT cell development. Nat Immunol. 3(11): 1069-74.

He Y-W, Beers C, Deftos ML, Ojala EW and KA Forbush. 2000. Down-regulation of the orphan nuclear receptor ROR? t is essential for T lymphocyte maturation. J Immunol 164 (11):5668-74.

Suzuki I, Martin S, Beers C, Boursalian TE and PJ Fink. 2000. Fas ligand costimulates the in vivo proliferation of CD8+ T cells. Submitted

Hsieh CS, deRoos P, Honey K, Beers C and AY Rudensky. 2002. A role for cathepsin L and cathepsin S in peptide generation for MHC class II presentation. J. Immunol. 168:2618-2625.

Barton GM, Beers C, deRoos P, Eastman SR, Gomez ME, Forbush KA and AY Rudensky. 2002. Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes. Proc. Natl. Acad. Sci. USA 99:6937-6942.

Blish CA, Dillon SR, Farr AG and PJ Fink. 1999. Anergic CD8+ T cells can persist and function in vivo. J Immunol. Jul 1;163(1):155-64.

Blish CA, Gallay BJ, Turk GL, Kline KM, Wheat W and PJ Fink. 1999. Chronic modulation of the TCR repertoire in the lymphoid periphery. J Immunol. Mar 15;162(6):3131-40.

Gantner BN, Simmons RM, Canavera SJ, Akira, S. and DM Underhill. 2003. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med. May 5; 197(9): 1107-17.

Carson BD, Ziegler SF. Impaired T cell receptor signaling in Foxp3+ CD4 T cells. Ann NY Acad Sci. 2007 Mar 21

Carson BD*, Lopes JE*, Soper DM*, Ziegler SF. Insights into transcriptional regulation by FOXP3. Front Biosci. 2006 May 1;11:1607-19. * Authors contributed equally to this work.

Polanczyk MJ, Carson BD, Subramanian S, Afentoulis M, Vandenbark AA, Ziegler SF and H Offner. 2004. Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment. J Immunol. Aug 15;173(4):2227-30.

Ohlen C, Kalos M, Cheng LE, Shur AC, Hong DJ, Carson BD, Kokot NC, Lerner CG, Sather BD, Huseby ES, and PD Greenberg. 2002. CD8(+) T Cell Tolerance to a Tumor-associated Antigen Is Maintained at the Level of Expansion Rather than Effector Function. J Exp Med. Jun 3;195(11):1407-18

Cheng LE, Ohlen C, Nelson BH and PD Greenberg. 2002. Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death. Proc Natl Acad Sci U S A. Mar 5;99(5):3001-6

Ohlen C, Kalos M, Cheng LE, Shur AC, Hong DJ, Carson BD, Kokot NC, Lerner CG, Sather BD, Huseby ES, and PD Greenberg. 2002. CD8(+) T Cell Tolerance to a Tumor-associated Antigen Is Maintained at the Level of Expansion Rather than Effector Function. J Exp Med. Jun 3;195(11):1407-18

Deftos ML and MJ Bevan. 2000. Notch signaling in T cell development. Curr Opin Immunol. 12:166-72.

He Y-W, Beers C, Deftos ML, Ojala EW, Forbush KA and MJ Bevan. 2000. Down regulation of the orphan nuclear receptor ROR? t is essential for T lymphocyte maturation. J. Immunol. 164:5668-5674.

Deftos M.L., Huang E, Ojala EW, Forbush KA and MJ Bevan. 2000. Notch-1 signalling promotes the maturation of CD4 and CD8 thymocytes. Immunity 13:73-84.

Deftos ML, He Y-W, Ojala EW and MJ Bevan. 1998. Correlating Notch signaling with thymocyte maturation. Immunity 9:777-786.

He YW, Deftos ML, Ojala EW and MJ Bevan. 1998. ROR? t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. Immunity 9:797-806.

Eastman S, Deftos M, DeRoos PC, Hsu DH, Teyton L, Braunstein NS, Hackett CJ and AY Rudensky. 1996. A study of complexes of class II invariant chain peptide: major histocompatibility complex class II molecules using a new complex-specific monoclonal antibody. Eur J Immunol. 26:385-93.

Dillon SR, MacKay VL and PJ Fink. 1995. A functionally compromised intermediate in extrathymic CD8+ T cell deletion. Immunity. 3:321-333.

Dillon SR and PJ Fink. 1995. Thymic selection events mediated by the pre-TCR do not depend upon a limiting ligand. Intl. Immunol. 7:1363-1373.

Dillon SR, Jameson SC and PJ Fink. 1994. V beta 5+ T cell receptors skew toward OVA+H-2Kb recognition. J. Immunol. 152:1790-1801.

Blish CA, Dillon SR, Farr AG and PJ Fink. 1999. Anergic CD8+ T cells can persist and function in vivo. J Immunol. 163:155-64.

Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, et al. 2000. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 408(6808):57-63

Gross JA, Johnston J, Mudri S, Enselman R, Dillon SR, Madden K, et al. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. 2000. Nature 404(6781):995-9.

Dillon SR, Constantinescu A and MS Schlissel. 2001. Annexin V binds to positively selected B cells. J Immunol 166(1):58-71.

Dillon SR, Mancini M, Rosen A and MS Schlissel. 2000. Annexin V binds to viable B cells and colocalizes with a marker of lipid rafts upon B cell receptor activation. J Immunol. 164:1322-32.

Han S, Dillon SR, Zheng B, Shimoda M, Schlissel MS and G Kelsoe. 1997. V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science. 278:301-5.

Kuball J, Dossett ML, Wolfl M, Ho WY, Voss RH, Fowler C, Greenberg PD. Facilitating matched pairing and expression of TCR chains introduced into human T cells. Blood. 2007 Mar 15. 109(6):2331-8.

Doty RT and EA Clark. 1996. Subcellular localization of CD80 receptors is dependent on an intact cytoplasmic tail and is required for CD28-dependent T cell costimulation. J. Immunol. 157:3270-3279.

Law CL, Aruffo A, Chandran KA, Doty RT and EA Clark. 1995. Ig domains 1 and 2 of murine CD22 constitute the ligand-binding domain and bind multiple sialylated Ligands expressed on B and T cells. J Immunol. 155:3368-76.

Doty RT and EA Clark. 1998. Two regions in the CD80 cytoplasmic rail regulate CD80 redistribution and cell costimulation. J Immunol 161:2700-7.

Doty RT, Xia D, Nguyen SP, Hathaway TR and DM Willerford. 1999. Promoter element for transcription of unrearranged T-cell receptor beta-chain gene in pro-T cells. Blood 93:3017-25.

Pinchuk LM, Grouard-Vogel G, Magaletti DM, Doty RT, Andres RG and EA Clark. 1999. Isolation and characterization of macaque dendritic cells from CD34(+) bone marrow progenitors. Cell Immunol. 196:34-40.

Fink PJ, Fang CA and GL Turk. 1994. The induction of peripheral tolerance by the chronic activation and deletion CD4+V beta 5+ cells. J Immunol 152:4270-81.

Finch RJ, Fields PE and PD Greenberg. 2001. A transcriptional block in the IL-2 promoter at the -150 AP-1 site in effector CD8+ T cells. J Immunol. Jun 1;166(11):6530-6.

Greenberg PD, Finch RJ, Gavin MA, Kalos M, Lewinsohn DA, Lonergan M, Lord JD, Nelson BH, Ohlen C, Sing AP, Warren EH, Yee C and SR Riddell. 1998. Genetic modification of T-cell clones for therapy of human viral and malignant diseases. Cander J Sci Am. May 4 Suppl 1:S100-5.

Fontenot JD and AY Rudensky. 2004. Molecular aspects of regulatory T cell development. Semin Immunol. Apr;16(2):73-80. Review.

Fontenot JD, Gavin MA and AY Rudensky. 2003. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. Apr;4(4):330-6. Epub 2003 Mar 03.

Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson DB, Schroeder L and AA Aderem. 2000. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci USA. 97 (25):13766-71.

Friend SL, Hosier S, Nelson A, Foxworthe D, Williams DE and A Farr. 1994. A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells. Exp. Hematol. 22:321-328.

Kuball J, Dossett ML, Wolfl M, Ho WY, Voss RH, Fowler C, Greenberg PD. Facilitating matched pairing and expression of TCR chains introduced into human T cells. Blood. 2007 Mar 15. 109(6):2331-8.

Gantner BN, Simmons RM, Underhill DM. 2005. Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. EMBO J. Feb 24.

Gantner BN, Simmons RM, Canavera SJ, Akira, S. and DM Underhill. 2003. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med. May 5; 197(9): 1107-17.

Norment AM, Bogatzki LY, Gantner BN and MJ Bevan. 2000. Murine CCR9, a chemokine receptor for thymus-expressed chemokine that is up-regulated following pre-TCR signaling. J Immunol. Jan 15;164(2):639-48.

Gavin MA and MJ Bevan. 1998. Major histocompatibility complex allele-specific peptide libraries and identification of T-cell memotopes. Methods Mol Biol. 87:235-48.

Gavin MA and MJ Bevan. 1995. Increased peptide promiscuity provides a rationale for the lack of N-regions in the neonatal T cell repertoire. Immunity 3:793-800.

Gavin MA, Dere B, Grandea III AG, Hogquist KA, and MJ Bevan. 1994. MHC class I allele specific for peptide libraries: Identification of peptides that mimic an H-Y T cell epitope. Eur. J. Immunol. 24:2124-2133.

Gavin MA, Gilbert MJ, Riddell SR, Greenberg PD and MJ Bevan. 1993. Alkali hydrolysis of recombinant proteins allows for the rapid identification of class I MHC-restricted CTL epitopes. J. Immunol. 151:3971-3980.

Hogquist KA, Gavin MA and MJ Bevan. 1993. Positive selection of CD8+ T cells induced by major histocompatibility complex binging peptides in fetal thymic organ culture. J Exp Med. 177:1469-73.

Warren EH, Gavin MA, Simpson E, Chandler P, Page DC, Disteche C, Stankey KA, Greenberg PD, Riddell SR. 2000. The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen. J Immunol. 164:2807-14.

Ehrmann IE, Ellis PS, Mazeyrat S, Duthie S, Brockdorff N, Mattei MG, Gavin MA, Affara NA, Brown GM, Simpson E, Mitchell MJ, Scott DM. 1998 Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. Hum Mol Genet 7:1725-37

Greenberg PD, Finch RJ, Gavin MA, Kalos M, Lewinsohn DA, Lonergan M, Lord JD, Nelson BH, Ohlen C, Sing AP, Warren EH, Yee C, and SR Riddell. 1998. Genetic modification of T-cell clones for therapy of human viral and malignant diseases. Cander J Sci Am. May; 4 Suppl 1:S100-5.

Gillard GO, Dooley J, Erickson M, Peltonen L, Farr AG. Aire-dependent alterations in medullary thymic epithelium indicate a role for aire in thymic epithelial differentation. J Immunol. 2007 Mar 1. 178(5):3007-15.

Erickson M, Morkowski S, Lehar S, Gillard G, Beers C, Dooley J, Rubin JS, Rudensky AY and AG Farr. 2002. Regulation of thymic epithelium by keratinocyte growth factor. Blood 100:3269-78.

Nakayama T, Kasprowicz DJ, Yamashita M, Schubert LA, Gillard G, Kimura M, Didierlaurent A, Koseki H and SF Ziegler. 2002. The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression. J Immunol. Jan 1;168(1):87-94.

Wong P, Goldrath AW and AY Rudensky. 2000. Competition for specific intrathymic ligands limits positive selection in a TCR transgenic model of CD4+ T cell development. J Immunol. Jun 15;164(12):6252-9

Goldrath AW, Bogatzki LY and MJ Bevan. 2000. Naïve T cells transiently acquire a memory-like phenotype during homeostasis driven proliferation. J Exp Med 192:557-564.

Goldrath AW and MJ Bevan. 1999. Selecting and maintaining a diverse T-cell repertoire. Nature 402:255-62.
Goldrath AW, and MJ Bevan. 1999. Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts. Immunity Aug;11(2):183-90.

Goldrath AW, Hogquist KA and MJ Bevan. 1997. CD8 lineage commitment in the absence of CD8. Immunity 6:663-642.

Brabb T, Goldrath AW, von Dassow P, Paez A, Liggitt HD and J Goverman. 1997. Triggers of auto-immune disease in a murine TCR-transgenic model for multiple sclerosis. J Immunol. 159:497-507.

Brossart P, Goldrath AW, Butz EA, Marin S and MJ Bevan. 1997. Virus-mediated delivery of antigenic epitopes into dendritic cells as a means to induce CTL. J Immunol. 158:3270-6.

Morkowski S, Goldrath AW, Eastman S, Ramachandra L, Freed DC, Whiteley P and AY Rudensky. 1995. T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates. J Exp Med. 182:1403-13.

Grubin CE, Kovats S, DeRoos P, and AY Rudensky. 1997. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity 7:197-208.

Kovats S, Grubin CE, Eastman S, DeRoos P, Dongre A, Van Kaer L, and AY Rudensky. 1998. Invariant chain-independent function of H-2M in the formation of endogene peptide-major histo-compatibility complex class II complexes in vivo. J Exp Med 187:245-51.

Su TT, Guo B, Wei B, Braun J and DJ Rawlings. 2004. Signaling in transitional type 2 B cells is critical for peripheral B-cell development. Immunol Rev. Feb;197:161-78. Review

Su TT, Guo B, (Co-First Authors) Kawakami Y, Sommer K, Chae K, Humphries LA, Kato RM, Kang S, Patrone L, Wall R, Teitell M, Leitges M, Kawakami T and DJ Rawlings. 2002. PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. Nat Immunol. Aug;3(8):780-6. Epub Jul 15.

Su TT, Guo B and DJ Rawlings. 2002. Emerging roles for PKC isoforms in immune cell function. Molecular Interventions 2:141.

Guo B, Kato RM, Garcia-Lloret M, Wahl MI and DJ Rawlings. 2000. Engagement of the Human Pre-B Cell Receptor Generates a Lipid Raft-Dependent Calcium Signaling Complex Immunity, Vol. 13, 243-253, August.

Hale JS, Boursalian TE, Turk GL, and PJ Fink. 2006 Thymic Output In Aged Mice. Proc Natl Acad Sci U S A. 103(22):8447-52.

Hale JS, Dahlem TJ, Margraf RL, Debnath I, Weis JJ, and JH Weis. 2006. Transcriptional control of Pactolus: evidence of a negative control region and comparison with its evolutionary paralogue, CD18 (beta2 integrin). J Leukoc Biol. 80(2):383-98.

Hamerman JA and AA Aderem. 2001. Function transitions in macrophages during in vivo infection with Mycobacterium bovis bacillus Calmette-Guerin. J. Immunol.167:2227-2233.

Page ST, Bogatzki LY, Hamerman JA, Sweenie CH, Hogarth PJ, Malissen M, Perlmutter RM, and AM Pullen. 1998. Intestinal intracepithelial lymphocytes include precursors committed to the T cell receptor ab lineage. Proc. Natl. Acad. Sci. USA 95:9459-9464.

Hamerman JA, Page ST, and AM Pullen. 1997. Distinct methylation states of the CD8ß gene in peripheral T cells and intraepithelial lymphocytes. J. Immunol. 159:1240-1246.

Hamerman JA, Page ST, and AM Pullen. 1997. Distinct methylation states of the CD8ß gene in peripheral T cells and intraepithelial lymphocytes. J. Immunol. 159:1240-1246.

Way SS, Havenar-Daughton C, Kolumam GA, Orgunn NN, Murali-Krishna, K. IL-12 and Type-1 IFN synergize for IFN-(gamma) production by CD4 T cells, whereas neither are required for IFN-(gamma) production by CD8 T cells after Listeria monocytogenes infection. J Immunol. 2007 Apr 1. 178(7):4498-505.

Havenar-Daughton C, Kolumam GA, Murali-Krishna K. 2006. Cutting Edge: The direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection. J Immunol, 176:3315-9.

Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Golldlett DR, Eng JK, Akira S, Underhill DM and AA Aderem. 2001. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410 (6832):1099-1103.

Werts C., Tapping RI, Mathison JC, Chuang TH, Kravechenko V, Saint Girons I, Hakke DA, Godowski PJ, Hayashi F, Ozinsky A, Underhill DM, Kirschning CJ, Wagner H, Aderem A, Tobias PS and Ulevitch RJ. 2001. Leptosprial lipopolysaccharide activates cells through a TLR2-dependent mechanism. Nature Immunol. 4:346-352.

Acosta-Rodriguez EV, Craxton A, Hendricks DW, Merino MC, Montes CL, Clark EA, Gruppi A. BAFF and LPS cooperate to induce B cells to become susceptible to CD95/Fas-mediated cell death. Eur J Immunol. 2007 Mar 13. (epub in advance of print).

Gavin MA, Torgerson TR, Houston E, DeRoos P, Ho WY, Stray-Pedersen A, Ocheltree EL, Greenberg PD, Ochs HD, Rudensky AY. Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6659-64. Epub 2006 Apr 14. Erratum in: Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9373

Nakagawa TY, Brissette WH, Lira PD, Griffiths RJ, Petrushova N, Stock J, McNeish JD, Eastman SE, Howard ED, Clarke SR, Rosloniec EF, Elliot EA and AY Rudensky. 1999. Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice. Immunity. 10:207-17.

Hsing LC, Rudensky AY. 2005. The lysosomal cysteine proteases in MHC class II antigen presentation. Immunol Rev., Oct 207:229-41.

Ohlen C, Kalos M, Cheng LE, Shur AC, Hong DJ, Carson BD, Kokot NC, Lerner CG, Sather BD, Huseby ES and PD Greenberg. 2002. CD8(+) T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector function. J Exp Med. Jun 3;195(11):1407-18.

Huseby, ES, Sather B, Huseby PG and J Goverman. 2001. Age dependent T cell tolerance and autoimmunity to myelin basic protein. Immunity 14:471-481.

Huseby ES and J Goverman. 2000. Tolerating the nervous system: a delicate balance. J Exp Med. 191:757-60.

Huseby ES, Ohlen C, and J Goverman. 1999. Cutting edge: myelin basic protein-specific cytotoxic T cell tolerance is maintained in vivo by a single dominant epitope in H-2k mice. J Immunol Aug 1;163(3):1115-8.

Loftus C, Huseby E, Gopaul P, Beeson C and J Goverman. 1999. Highly cross-reactive T cell responses to myelin basic protein epitopes reveal a nonpredictable form of TCR degeneracy. J Immunol 162:6451-7.

Goverman J, Brabb T, Huseby ES and AG Farr. 1997. TCR signaling regulates thymic organization: lessons from TCR-transgenic mice. Immunol Today. 18:204-8.

Iritani BM, Forbush KA, Farrar MA, and RM Perlmutter. 1997. Control of B cell development by Ras-mediated activation of Raf. EMBO J. 16:7019-7031.

Iritani BM, Alberola-Ila J, Forbush KA and RM Perlmutter. 1999. Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors. Immunity. Jun;10(6):713-22.

Volna P, Jarjour J, Baxter S, Roffler SR, Monnat RJ Jr, Stoddard BL, Scharenberg AM. Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleases. Nucleic Acids Res. 2007 Apr 10; [Epub ahead of print]

Kerner JD, Appleby MW, Mohr RN, Chien S, Rawlings DJ, Maliszewski CR, Witte ON, and RM Perlmutter. 1995. Impaired expansion of mouse B cell progenitors lacking Btk. Immunity 3:301-312.

Kosoy R and P Concannon. 2005. Functional variants in SUMO4, TAB2, and NFkappaB and the risk of type 1 diabetes. Genes Immun. Feb 24.

Kosoy R, Yokoi N, Seino S and P Concannon. 2004. Polymorphic variation in the CBLB gene in human type 1 diabetes. Genes Immun. 2004 May;5(3):232-5.

Dahlman I, Eaves IA, Kosoy R, Morrison VA, Heward J, Gough SC, Allahabadia A, Franklyn JA, Tuomilehto J, Tuomilehot-Wolf E., Cucca F, Guja C, Ionexcu-Tirgoviste C, Stevens H, Carr P, Nutland S, McKinney P, Shiield JP, Wang W, Cordell HJ, Walkerm N, Todd JA and P Concannon. 2002. Parameters for reliable results in genetic association studies in common disease. Nature Genet 30(2):149-150

Lehar SM, Dooley J, Farr AG and MJ Bevan. 2005. Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors. Blood. 2005 Feb 15;105(4):1440-7. Epub 2004 Oct 14.Lehar SM, Bevan MJ. 2004. Immunology: polarizing a T-cell response. Nature. Jul 8;430(6996):150-1

Huang EY, Gallegos AM, Richards SM, Lehar SM and MJ BevanJ. 2003. Surface expression of Notch1 on thymocytes: correlation with the double-negative to double-positive transition. J Immunol. Sep 1;171(5):2296-304.
Lehar SM and MJ Bevan. 2002. T cell development in culture. Immunity. 2002 Dec;17(6):689-92. Review. PMID: 12479815

Lee PP, Fitzpatrick DR, Beard C, Jessup HK, Lehar SM, Makar KW, Perez-Melgosa M, Sweetser, MT, Schlissel MS, Nguyen S, Cherry SR, Tsai JH, Tucker S, Weaver WM, Kelso A, Jaenisch R and CB Wilson. 2001. A critical role for Dnmt1 and DNA methylation in T cell development, function and survival. Immunity 15:763-774.

den Haan JM, Lehar SM and MJ Bevan. 2000. CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo. J Exp Med. Dec 18;192(12):1685-96.

Lenz LL, Butz EA and MJ Bevan. 2000. Requirements for bone marrow-derived antigen presenting cells in priming cytotoxic T cell responses to intracellular pathogens. J. Exp. Med. 192:1135-1142.

Princiota MF, Lenz LL, Bevan MJ and UD Staerz. 1998. H2-M3 restricted presentation of a Listeria-derived leader peptide. J Exp Med 187:1711-9.

Lenz LL and MJ Bevan. 1997. CTL responses to H2-M3-restricted Listeria epitopes. Immunol. Rev. 158:115-121.
Harty JT, Lenz LL and MJ Bevan. 1996. Primary and secondary immune responses to Listeria monocytogenes. Curr Opin Immunol 8:526-30.

Lenz LL, Dere B and MJ Bevan. 1996. Identification of an H2-M3-restricted Listeria epitope: implications for antigen presentation by M3. Immunity 5-63-72.

Lenz LL and MJ Bevan. 1996. H2-M3-restricted presentation of Listeria monocytogenes antigens. Immunol. Rev. 151:107-121.

Marshall AJ, Niiro H, Lerner CG, Yun TJ, Thomas S, Disteche CM and EA Clark. 2000. A novel B lymphocyte-associated adaptor protein, bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase. J Exp Med. 191:1319-32.

Ohlen C, Kalos M, Cheng LE, Shur AC, Hong DJ, Carson BD, Kokot NC, Lerner CG, Sather BD, Huseby ES, and PD Greenberg. 2002. CD8(+) T Cell Tolerance to a Tumor-associated Antigen Is Maintained at the Level of Expansion Rather than Effector Function. J Exp Med. Jun 3;195(11):1407-18

Way SS, Thompson L, Lopes J, Hajjar AM, Kollmann TR, Freitag,NE, and CB Wilson. 2004. Characterization of flagellin expression and its role in Listeria monocytogenes infection and immunity. Cell Microbio. 6:235-242

Martino A, Holmes JH, Lord JD, Moon JJ and BH Nelson. 2001. Stat5 and SP1 regulate transcription of the cyclin D2 gene in response to Interleukin-2. J. Immunol. 166:1723-1729.

Gu H, Maeda H, Moon JJ, Lord JD, Yoakim M, Nelson BH and BG Neel. 2000. A new role for Shc in activation of the PI-3K/Akt pathway. Mol Cell Biol. 20:7109-20.

Lord JD, McIntosh BC, Greenberg PD and BH Nelson. 2000. The IL-2 receptor promotes lymphocyte proliferation and induction of the cmyc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5. J Immunol. 164:2533-41.

Van Parijs L, Refaeli Y, Lord JD, Nelson BH, Abbas AK and D Baltimore. 1999. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity 11:281-8.

Hunt AE, Lali FV, Lord JD, Nelson BH, Miyazaki T, Tracey KJ and BM Foxwell. 1999. Role of interleukin (IL)-2 receptor beta-chain subdomains and Shc in p38 mitogen-activated protein (MAP) kinase and p54 MAP kinase (stress-activated protein Kinase/c-Jun N-terminal Kinase) activation. IL-2-driven proliferation is independent of p38 and p54 MAP kinase activation. J Biol Chem. 2;74:7591-7.

Lord JD, McIntosh BC, Greenberg, PD, and BH Nelson. 1998. The IL-2 receptor promotes proliferation bcl-2 and bcl-x induction, but not cell viability through the adaptor molecule Shc. J. Immunol. 161:4627-4633.

Greenberg PD, Finch RJ, Gavin MA, Kalos M, Lewinsohn DA, Lonergan M, Lord JD, Nelson BH, Ohlen C, Sing AP, Warren EH, Yee C and SR Riddell. 1998. Genetic modification of T-cell clones for therapy of human viral and malignant diseases. Cander J Sci Am. May; 4 Suppl 1:S100-5.

Nelson BH, Lord JD and PD Greenberg. 1996. A membrane-proximal region of the interleukin-2 receptor gamma c chain sufficient for Jak kinases activation and induction of proliferation in T cells. Mol Cell Biol. 16:309-17.

Nelson BH, Lord JD and PD Greenberg. 1994. Cytoplasmic domains of the interleukin-2 receptor beta and gamma chains mediate the signal for T-cell proliferation. Nature 369:333-6.

Pitcher LA, Mathis MA, Young JA, Deford LM, Purtic B, Wulfing C, van Oers NS. The CD3 gammaepsilon/deltaepsilon signaling module provides normal T cell functions in the absence of the TCR zeta immunoreceptor tyrosine-based activation motifs. Eur J Immunol. 2005 Dec; 35(12):3643-54.

Pitcher LA, Mathis MA, Subramanian S, Young JA, Wakeland EK, Love PE, van Oers NS. Selective expression of the 21-kilodalton tyrosine-phosphorylated form of TCR zeta promotes the emergence of T cells with autoreactive potential. J Immunol. 2005 May 15; 174(10):6071-9.

Sozio MS, Mathis MA, Young JA, Walchli S, Pitcher LA, Wrage PC, Bartok B, Campbell A, Watts JD, Aebersold R, Van Huijsduijnen RH, van Oers NS. PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit. J Biol Chem. 2004 Feb 27; 279(9):7760-9.

Pitcher LA, Young JA, Mathis MA, Wrage PC, Bartok B, van Oers NS. The formation and functions of the 21- and 23-kDa tyrosine-phosphorylated TCR zeta subunits. Immunol Rev. 2003 Feb;191:47-61. Review.

Coles MC, McMahon CW, Takizawa H and DH Raulet. 2000. Memory CD8 T lymphocytes express inhibitory MHC-specific Ly49 receptors. Eur J Immunol. 30:236-44.

Hanke T, Takizawa H, McMahon CW, Busch DH, Pamer EG, Miller JD, Altman JD, Liu Y, Cado D, Lemonnier FA, Bjorkman PJ and DH Raulet. 1999. Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity. 11:67-77.

McMahon CW, Traxler B, Grigg MD and AM Pullen. 1998. Transposon-mediated random insertions and site-directed mutagenesis prevent the trafficking of a mouse mammary tumor virus superantigen. Virology 243:354-65.

Grigg ME, McMahon CW, Morkowski S, Rudensky AY and AM Pullen. 1998. Mtv-1 superantigen trafficks independently of major histocompatibility complex class II directly to the B-cell surface by the exocytic pathway. J Virol 72:2577-88.

McMahon CW, Bogatski LY and AM Pullen. 1997. Mouse mammary tumor virus superantigens require N-linked glycosylation for effective presentation to T cells. Virology 228:161-170.

Beima KM, Miazgowicz MM, Lewis MD, Yan PS, Huang TH, Weinmann AS. T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects. J Biol Chem. 2006 Apr 28;281(17):11992-2000

Yun TJ, Tallquist MD, Aicher A, Rafferty KL, Marshall AJ, Moon JJ, Ewings MK, Mauhaupt M, Herring SW and EA Clark. 2001. Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function. Immunity. J Immunol 166:1482-1491.

Martino A, Holmes IV JH, Lord JD, Moon JJ and BH Nelson. 2001. Stat5 and Sp1 regulate transcription of the cyclin D2 gene in response to IL-2. J Immunol 166:1723-1729.

Moon, JJ and BH Nelson. 2001. Phosphatidylinositol 3-kinase potentiates, but does not trigger, T cell proliferation mediated by the IL-2 receptor. J. Immunol. 167:2714-2723.

Gu H, Maeda H, Moon JJ, Lord JD, Yoakim M, Nelson BH and Neel BG. 2000. New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway. Mol Cell Biol 20:7109-7120.

Otipoby KL, Draves KE and Clark EA. 2001. CD22 regulates BCR-mediated signals via two domains that independently recruit Grb2 and SHP-1. J. Biol. Chem. 276:44315-44322.

Otipoby KL, Andersson KB, Draves KE, Klaus SJ, Farr AG, Kerner JD, Perlmutter RM, Law CL and EA Clark. 1996. CD22 regulates thymus-independent responses and the lifespan of B cells. Nature 384:634-637.

Brabb T, Goldrath AW, von Dassow P, Paez A, Liggitt HD and J Goverman. 1997. Triggers of autoimmune disease in a murine TCR-transgenic model for multiple sclerosis. J Immunol. 159:497-507.

Page ST, Bogatzki LY, Hamerman JA, Malissen M, Perlmutter RM and AM Pullen. 1999. Differential effects of manipulating signaling in early T cell development in intestinal intraepithelial lymphocytes and thymocytes. Int Immunol Feb; 11(2): 169-77.

Page ST, Bogatzki LY, Hamerman JA, Sweenie CH, Hogarth PJ, Malissen M, Perlmutter RM and AM Pullen. 1998. Intestinal intracepithelial lymphocytes include precursors committed to the T cell receptor ab lineage. Proc. Natl. Acad. Sci. USA 95:9459-9464.

Page ST, van Oers NS, Perlmutter RM, Weiss A and AM Pullen. 1997. Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development. Eur. J. Immunol. 27:554-562.

Perchellet A, Stromnes I, Pang JM, Goverman J. CD8+ T cells maintain tolerance to myelin basic protein by 'epitope theft'. Nat Immunol. 2004 Jun;5(6):606-14. Epub 2004 May 16.

Roach JC, Wang K, Gan L, and L Hood. 1997. The molecular evolution of the vertebrate trypsinogens. J. Mol. Evol. 45:640-652.

Roach JC, Boysen C, Wang K and L Hood. 1995. Pairwise end sequencing: a unified approach to genomic mapping and sequencing. Genomics 26:345-353.

Teague RM, Sather BD, Sacks JA, Huang MZ, Dossett M, Morimoto J, Tan > X, Sutton S, Cooke M, Ohlen C, Greenberg PD. 2006. Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors. Nature Medicine 12:335-341.

Schoenborn JR, Dorschner M, Sekimata M, Santer D, Shnyreva M, Fitzpatrick DR, Stamatoyonnapoulos JA, Wilson CB. Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing Ifng transcription. Nature Immunology. 2007 (in press).

Brabb T, von Dassow P, Ordonez N, Schnabel B, Duke B (Sather) and J. Goverman. In Situ tolerance within the central nervous system as a mechanism for preventing autoimmunity. J. Exp Med. 2000; 192:871-880.

Ohlen C, Kalos M, Cheng LE, Shur AC, Hong DJ, Carson BD, Kokot NC, Lerner CG, Sather BD, Huseby ES, and PD Greenberg. 2002. CD8(+) T Cell Tolerance to a Tumor-associated Antigen Is Maintained at the Level of Expansion Rather than Effector Function. J Exp Med. Jun 3;195(11):1407-18

Huseby ES, Sather BD, Huseby PG and J. Goverman. Age-dependant T cell tolerance and autoimmunity to myelin basic protein. Immunity. 2001; 14:471-481.

Teague RM, Sather BD, Sacks JA, Huang MZ, Dossett M, Morimoto J, Tan > X, Sutton S, Cooke M, Ohlen C, Greenberg PD. 2006. Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors. Nature Medicine 12:335-341.

Cabbage SE, Huseby ES, Sather BD, Brabb T, Liggitt D, and Joan Goverman Regulatory T Cells Maintain Long-Term Tolerance to Myelin Basic Protein by Inducing a Novel, Dynamic State of T Cell Tolerance. J. Of Immunol. 2007; Jan 15. Vol.178, No.2

Humblet-Baron S*, Sather BD*, Anover S, Becker-Herman S, Kasprowicz DJ, Khim S, Nguyen T, Hudkins-Loya K, Alpers CE, Ziegler S, Ochs H, Torgerson T, Campbell DJ, and DJ Rawlings. Wiskott Aldrich Syndrome Protein is Required for Regulatory T Cell Homeostasis. Accepted for publication in Feb 2007 issue of JCI *Authors contributed equally to this work

Wilson CB, Schoenborn J. BACing up the interferon-gamma locus. Immunity. 2006 Nov;25(5):691-3.

Schoenborn JR, Dorschner M, Sekimata M, Santer D, Shnyreva M, Fitzpatrick DR, Stamatoyonnapoulos JA, Wilson CB. Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing Ifng transcription. Nature Immunology. 2007 (in press).

Wilson CB, Schoenborn J. Cellular and molecular regulation of IFN-gamma in innate and adaptive immunity. Advances in Immunology Reviews. 2007 (in press).

Cron RQ, Schubert LA, Lewis DB, and CC Hughes. 1997. Consistent transient transfection of DNA into non-transformed human and murine T-lymphocytes. J Immunol Methods. 205(2):145-50.

Dolganov G, Bort S, Lovett M, Burr J, Schubert L, Short D, McGurn M, Gibson C and DB Lewis. 1996. Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31. Blood 87(8):3316-26.

Schubert LA, King G, Cron RQ, Lewis DB, Aruffo A, and D. Hollenbaugh. 1995. The human gp39 promoter. Two distinct nuclear factors of activated T cell protein-binding elements contribute independently to transcriptional activation. J. Biol. Chem. 270(50):29624-7.

Kollmann TR, Reikie B, Blimkie D, Way SS, Hajjar AM, Arispe K, Shaulov A, Wilson CB. Induction of protective immunity to Listeria monocytogenes in neonates. J Immunol. 2007 Mar 15. 178(6):3695-701.

Sohn SJ, Forbush KA, Nguyen N, Whitthuhn B, Nosaka T, Ihle JN and RM Perlmutter. 1998. Requirement for Jak3 in mature T cells: its role in regulation of T cell homeostasis. J. Immunol. 160:2130-2138.

Hashimoto K, Sohn SJ, Levin SD, Tada T, Perlmutter RM and T Nakayama. 1996. Requirement for p561ck tyrosine kinase activation in T cell receptor-mediated thymic selection. J Exp Med. 184:931-43.

Hernandez-Hoyos G, Sohn SJ, Rothenberg EV and J Alberola-Ila. 2000. Lck activity controls CD4/Cd8 T cell lineage commitment. Immunity 12:313-22.

Boursalian TE, Golob J, Soper DM, Cooper CJ, Fink PJ. Continued maturation of thymic emigrants in the periphery. Nature Immunology 2004 Apr;5(4):418-25.

Kasprowicz DJ, Droin N, Soper DM, Ramsdell F, Green D, Ziegler SF. Dynamic regulation of Foxp3 expression regulates the balance between CD4+ T cell activation and cell death. Eur J Immunol. 2005 Dec;35(12):3424-32.

Carson BD*, Lopes JE*, Soper DM*, Ziegler SF. Insights into transcriptional regulation by FOXP3. Front Biosci. 2006 May 1;11:1607-19. * Authors contributed equally to this work.

Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth B, Clayberger C, Soper DM, Ziegler SF, Bluestone JA. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med. 2006 Jul 10;203(7):1701-11.

Soper DM, Kasprowicz DJ, Ziegler SF. IL-2R links IL-2R signaling with Foxp3 Expression. Preliminary acceptance at Eur J Immunol.

Stromnes I, Goverman J. Active induction of experimental allergic encephalomyelitis. Nov 2006. Nature Protocols 1810-1819.

Stromnes IM, Goverman J. Passive induction of experimental allergic encephalomyelitis. Nov 2006. Nature Protocols 1952-1960.

Stromnes IM, Goverman JM. Osteopontin-induced survival of T cells. Nat Immunol. 2007 Jan;8(1):19-20. No abstract available. PMID: 17179966 [PubMed - indexed for MEDLINE

Beaty JS, Sukiennicki TL and GT Nepom. 1999. Allelic variation in transcription modulated MHC class II expression and function. Microbes Infect. 1:919-27.

Sukiennicki TL, Shewey LM and GT Nepom. 1993. Locus- and allele-specific DNA-protein interactions in the HLA-DQB1 X box. Immunol Res; 12(4):317-29

Sun JC, Williams MA and MJ Bevan. 2004. CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection. Nat Immunol. 5:927-33.

Sun JC and MJ Bevan. 2004. Cutting edge: long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cells. J Immunol. 172:3385-9.

Tyznik AJ, Sun JC and MJ Bevan. 2004. The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells. J Exp Med. 199:559-65.

Sun JC and MJ Bevan. 2003. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science. 300:339-42.

Urdahl KB, Sun JC and MJ Bevan. 2002. Positive selection of MHC class Ib-restricted CD8+ T cells on hematopoietic cells. Nat Immunol. 3:772-9.

Sun, M., Richards, S., Prasad, D.V.R., Mai, X.M., Rudensky, A., and Dong, C. 2002. Characterization of Mouse and Human B7-H3 Genes. J. Immunol. 168: 6294

Cooper, C.J., Turk, G.L., Sun, M., Farr, A.G., and Fink, P.J. 2004. TCR Reversion Occurs in Germinal Centers. J. Immunol. 173: 6532

Sun, M., Ames, K.T., Suzuki, I., and Fink, P.J. 2006. The Cytoplasmic Domain of Fas Ligand Costimulates TCR Signals. J. Immunol. 177: 1481

Suzuki I, Martin S, Beers C, Boursalian TE and PJ Fink. 2000. Fas ligand costimulates the in vivo proliferation of CD8+ T cells. Submitted

Suzuki I and PJ Fink. 2000. The dual functions of Fas ligand in the regulation of peripheral CD8+ and CD4+ T cells. Proc Natl Acad Sci USA 97(4):1707-12.

Suzuki I and PJ Fink. 1998. Maximal proliferation of cytotoxic T lymphocytes requires reverse signaling through Fas ligand. J. Exp. Med. 187:123-128.

Swan KA, Severson AF, Carter JC, Martin PR, Schnabel H, Schnabel R and B Bowerman. 1998. cyk-1: a C. elegans FH gene required for a late step in embryonic cytokines. J Cell Sci. 111:2017-27.

Alberola-Ila J, Hogquist KA, Swan KA, Bevan MJ and RM Perlmutter. 1996. Positive and negative selection invoke distinct signaling pathways. J Exp Med 184:9-18.

Swan KA, Alberola-Ila, J, Gross JA, Appleby MW, Thomas JF and RM Perlmutter. 1995. Involvement of p21ras distinguishes positive and negative selection in thymocytes. EMBO J. 14:276-285.

Thompson LJ, Kolumam GA, Thomas S, Murali-Krishna K. J . Innate inflammatory signals induced by various pathogens differentially dictate the IFN-I dependence of CD8 T cells for clonal expansion and memory formation. Immunol. 2006 Aug 1;177(3):1746-54

Kolumam GA, Thomas S, Thompson LJ, Sprent J, Murali-Krishna K. Epub 2005 Aug 29. Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J Exp Med. 2005 Sep 5;202(5):637-50.

Way SS, Thompson L, Lopes J, Hajjar AM, Kollmann TR, Freitag NE, and CB Wilson. 2004. Characterization of flagellin expression and its role in Listeria monocytogenes infection and immunity. Cell Microbio. 6:235-242

Stone B, Schummer M, Paley PJ, Thompson L, Stewart J, Ford M, Crawford M, Urban N, O'Briant K, Nelson BH.Serologic analysis of ovarian tumor antigens reveals a bias toward antigens encoded on 17q. Int J Cancer. 2003 Mar 10;104(1):73-84.

Nelson BH, Martyak TP, Thompson LJ, Moon JJ, Wang T. Uncoupling of promitogenic and antiapoptotic functions of IL-2 by Smad-dependent TGF-beta signaling. J Immunol. 2003 Jun 1;170(11):5563-70.

Matthews SA, Dayalu R, Thompson LJ, Scharenberg AM. Regulation of protein kinase Cnu by the B-cell antigen receptor. J Biol Chem. 2003 Mar 14;278(11):9086-91. Epub 2002 Dec 27.

Tucker SN, Jessup HK, Fujii H and CB Wilson. 2002. Enforced Expression of the Ikaros Isoform IK5 Decreases the Numbers of Extrathymic IEL and NK1.1+ T Cells. Blood 99:513-9.

Lee PP, Fitzpatrick DR, Beard C, Jessup HK, Lehar S, Makar KW, Perez-Melgosa M, Sweetser, MT, Schlissel MS, Nguyen S, Cherry SR, Tsai JH, Tucker S, Weaver WM, Kelso A, Jaenisch R and CB Wilson. 2001. A critical role for Dnmt1 and DNA methylation in T cell development, function and survival. Immunity 15:763-774

Williams MA, Tyznik AJ, Bevan MJ. Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells. Nature. 2006 Jun 15;441(7095):890-3.

Kasprowicz DJ, Smallwood PS, Tyznik AJ, Ziegler SF. Scurfin (FoxP3) controls T-dependent immune responses in vivo through regulation of CD4+ T cell effector function. J Immunol. 2003 Aug 1;171(3):1216-23.

Hsieh CS, Liang Y, Tyznik AJ, Self SG, Liggitt D and AY Rudensky. 2004. Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity. Aug; 21(2):267-77.

Tyznik AJ, Sun JC and MJ Bevan. 2004. The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells. J Exp Med. 199:559-65.

Buckner FS, Wipke BT and WC Van Voorhis. 1997. Trypanosoma cruzi infection does not impair major histocompatibility complex class I presentation of antigen to cytotoxic T lymphocytes. Eur J Immunol. 27:2541-8.

Wipke BT, Jameson SC, Bevan MJ, and EG Pamer. 1993. Variable binding affinities of listeriolysin O peptides for the H-2Kd class I molecule. Eur J Immunol Aug;23(8):2005-10.

Beers C, Burich A, Kleijmeer MJ, Griffith JM, Wong P and AY Rudensky. 2005. Cathepsin S controls MHC class II-mediated antigen presentation by epithelial cells in vivo. J Immunol. 2005 Feb 1;174(3):1205-12.

Wong P, Barton GM, Forbush KA and AY Rudensky. 2001. Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands. J Exp Med. May 21;193(10):1179-87.

Wong P, Goldrath AW and AY Rudensky. 2000. Competition for specific intrathymic ligands limits positive selection in a TCR transgenic model of CD4+ T cell development. J Immunol. 2000 Jun 15;164(12):6252-9

Wong P and AY Rudensky. 1996. Phenotype and function of CD4+ T cells in mice lacking invariant chain. J. Immunol. 156:2133-2142.

Nakagawa, T., W. Roth, P. Wong, Nelson A, Farr A, Deussing J, Villadangos JA, Ploegh H, Peters HC and AY Rudensky. 1998. Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science, 280: 450-453.

Liljedahl, M., Winqvist O, Surh CD, Wong P, Ngo K, Teyton L, Peterson PA, Brunmark A, AY Rudensky, Fung-Leung W-P and L Karlsson. 1998. Altered antigen presentation in mice lacking H2-0. Immunity, 8: 233-243.

Updated 4-26-07