Transgenic Research Reagents - Department of Immunology UWSOM

Aerial view of facilities.

Transgenic Research Reagents

Knock-out/mutant mice in departmental laboratories

Investigator	Knockout/mutant strains maintained
Mike Bevan	OT-1 (TCR tg) P14 (TCR TG)
Ed Clark	B6.BL-8 high affinity NP+ BCR Tg B6.BL-8 low affinity NP+ BCR Tg B10.BR-H2k H2-T18a/SgSnJ B6.BAFF-Receptor KO B6.Bam-32 KO B6.Gp91 KO B6.Bam-32/Gp91 Double KO B6.Bim KO B6.Caspase-6 KO B6.CD11c-DTR B6.CD22 KO B6.CD22 KO/BL-8 high affinity NP+ Tg B6.CD22 KO/BL-8 low affinity NP+ Tg B6.CD40 KO B6.Fcerg1 Tg B6.GADS KO B6.BDCA-2 Tg B6.MHC II KO B6.Nos-2 KO B6.OT-I B6.OT-II B6.TCR KO B6.VDJ9k5
Pam Fink	B6 1pr floxed Fas dLCK-Cre Tg CD4 KO on a B6 background IAb KO mBcl-2 Tg (expressed in T cells) MTV negative wild-derived mice floxed Rag Rosa-YFP(stop) Cre reporter CD19 Cre knock in FasL KO RIPmOVA Tg Plt B6 mice TCRa KO TCRbd KO Bim KO IL-7Ra Tg Ly5 congenic B6 RAG2p-GFP Tg reporter mice on B6 background TCRTg B6: OT-1, OT-II, SMARTA, P14
Michael Gale	C57BL6 Caspase-1 KO FoxP3-DTR KO IFNb yfp (MOB) KO IFN-IR KO Ikbke (Ikkepsilon) KO IKKgamma (NEMO) IL-12 Rb2 KO IPS-1 KO IPS-1 WT LGP2 KO LGP2 KO x IFN-IR KO (in progress) MDA5 KO MyD88 KO P58 RIG-I KO RIG-I WT RIG-I KO x MDA5 KO (in progress) STI KO STI KO x IFNb yfp KO (in progress) STI KO x MyD88 KO (in progress) Sting KO Sting WT Sting KO x STI KO (in progress) Tbet KO TLR3 KO TNK-1 (Kos-1) KO
Joan Goverman	Rag1-1- on H-2u & H-2b * Ca -1- on H-2u CD4-1- on H-2u MBP-1-on H-2u, H-2h, H2d MBP TCR tg al in K wing except * - modified SPF 6th floor
Dan Stetson	IFNAR1 KO Ly5.1 TCRa KO uMT KO MyD88 KO B6 RAG2 KO MX-Cre Rosa26-eYFP floxed reporter B6.Nba2 IRF3 KO (permission required from Taniguchi) BALB/c

updated November 2009

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