June 10, 2012
Computer-designed proteins programmed to disarm a variety of flu viruses
As reported in the latest issue of Nature Biotechnology, David Baker and scientists at the IPD publish exciting new methods to improve the potency and breadth of computer-designed protein inhibitors of influenza.
The ability to engineer structures of protein complexes and to design interactions of high affinity and specificity would have countless applications in biology, medicine and public health. With the advent of next-generation sequencing, this long-standing goal may now be within reach. Exciting new methods that combine sequencing with techniques for protein display and selection allow the functional properties of hundred of thousands of mutants to be measured simultaneously. Also called ‘deep mutational scanning’, this approach is exploited in a milestone study in this issue by Baker and colleagues to optimize the binding properties of two computationally designed protein inhibitors of H1N1 influenza hemagglutinin.
Read the entire article here.