Institute for Stem Cell & Regenerative Medicine

at the University of Washington

2015 John H. Tietze Stem Cell Scientist Research Award

Akio Kobayashi PhD, Assistant Professor, Medicine (Nephrology)

With kidney diseases, the functional units of the kidney, the
nephrons, are lost, while the surrounding renal interstitium expands. However, the mammalian kidneys cannot create new nephrons in adults to restore kidney function. The goal of the proposed study is to establish an animal model for regenerative therapy for kidney disease by reprogramming nephron cells from renal interstitial cells. Our proposed studies should lay the foundation to establish novel regenerative therapy by creating new nephrons in diseased kidneys, which ultimately eliminates the need of dialysis and renal transplantation for patients with kidney diseases.