ISCRM

Aging

Cecilia Giachelli (Bioengineering)
My lab is interested in applying stem cell and regenerative medicine strategies to the areas of ectopic calcification, tissue engineering, biomaterials development and biocompatibility.

Ray Monnat, PhD (Pathology and Genome Sciences)
Our research focuses on human RecQ helicase deficiency syndromes such as Werner syndrome; high resolution analyses of DNA replication dynamics; and the engineering of homing endonucleases for targeted gene modification or repair in human and other animal cells.

David Parichy (Biology)
Our research program uses the zebrafish and related species to answer a variety of biological questions having both basic and translational relevance. Current efforts are focusing on: the establishment, maintenance, and recruitment of post-embryonic stem cells in the context of normal development, evolutionary diversification, and melanoma; the genes and cell behaviors underlying adult pigment pattern formation and how these mechanisms have evolved between closely related species to generate strikingly different pigment patterns; and the molecular mechanisms of the larval-to-adult transformation, or metamorphosis, which generates the adult form.

Peter Rabinovich (Pathology)
Recent scientific advances have demonstrated that aging is not the immutable process it was once thought to be. A variety of genetic, cellular, and, nutritional interventions not only increase longevity in laboratory organisms, but also dramatically increase the duration of disease-free life. The connection between health and aging is dramatic, as the major causes of human mortality increase exponentially with age, and modest reductions in the rate of aging have dramatic effects on the time of onset of heart disease, cancer, diabetes, etc. There is also a very close connection between aging and regenerative medicine, as we and others believe that that the onset of many diseases of aging is related to a decline in maintenance and repair capacities of cells and organs.

Investigators in the biology of aging at the University of Washington study interventions in the aging process in a variety of organisms, spanning yeast, nematodes, mice and humans. Genetic regulation of lifespan and cellular repair capacities is a special focus of our work. We are excited about the potentials for interaction of work in this field with studies of stem cells and regenerative medicine and believe that the confluence of these fields is a fertile area for rapid advancement.

Norm Wolf (Pathology)
Stem cell location and identity of the lens epithelium; The role of Sirt1 in lens metabolism and replication; The gene message expressions of the central zone of the lens and, separately, of the germinative zone that is lateral to it. The identity and changes with aging of the repair enzymes active in repair after oxidative damage to the lens epithelium.

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