ISCRM

Orthopaedics/Sports Medicine

Christopher Allen, MD (Orthopaedics and Sports Medicine)
Digit regeneration in humans. Children regrow amputated digit tips, a unique instance of complex tissue regeneration in humans. The process is not well-understood at the cellular or molecular level. Our lab has developed and reported the first human fetal digit model of response to digit tip amputation. We have also provided the first evidence in humans that the regeneration-associated transcription repressor Msx-1 may be involved in this process. Insights like this may form the basis for future cellular, tissue-engineered, or gene therapies to stimulate regeneration after extremity injury or amputation.

Cecilia Giachelli (Bioengineering)
My lab is interested in applying stem cell and regenerative medicine strategies to the areas of ectopic calcification, tissue engineering, biomaterials development and biocompatibility.

Frederick Matsen (Chair of Orthopaedics)
This group of clinicians is successfully developing regenerative medicine approaches to sports injuries.

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