Jay W. Heinecke, MD
Professor of Medicine
Research in the Heinecke laboratory focuses on understanding the role of macrophages in the pathogenesis of atherosclerosis, obesity, and insulin resistance. Major efforts focus on using a proteomics approach to identify specific proteins targeted for posttranslational modifications and building a systems biology view of the macrophage. Current studies include: (1) Investigating oxidative pathways that regulate the activities of high-density lipoprotein (HDL) and matrix metalloproteinases (MMPs), which are of central importance in atherosclerosis; (2) Use of animals with genetically engineered deficiencies to understand the role of oxidants and proteases in the pathogenesis of vascular disease and obesity; (3) Identifying macrophage protein networks involved in atherogenesis; and (4) Translational studies exploring the links between the HDL proteome, the macrophage proteome, and susceptibility to cardiovascular disease.