Jay W. Heinecke MD
University of Washington
Medicine/Metabolism, Endocrinology & Nutrition
Research in the Heinecke laboratory focuses on understanding the role of macrophages in the pathogenesis of atherosclerosis, obesity, and insulin resistance. Major efforts focus on using a proteomics approach to identify specific proteins targeted for posttranslational modifications and building a systems biology view of the macrophage. Current studies include: (1) Investigating oxidative pathways that regulate the activities of high-density lipoprotein (HDL) and matrix metalloproteinases (MMPs), which are of central importance in atherosclerosis; (2) Use of animals with genetically engineered deficiencies to understand the role of oxidants and proteases in the pathogenesis of vascular disease and obesity; (3) Identifying macrophage protein networks involved in atherogenesis; and (4) Translational studies exploring the links between the HDL proteome, the macrophage proteome, and susceptibility to cardiovascular disease.