Norman S. Wolf, DVM, PhD
My laboratory is attempting to determine the cell surface antigens that would identify a stem cell for the lens surface cells, as well as the proliferation capacity of this proposed cell. The lens surface consists of a single layer of nearly identical in appearance epithelial cells. There have been several suggestions from the field of research that the frontally located central zone of these cells contains a primitive cell reservoir for the more laterally located lens surface cells. The central zone cells cannot be shown to replicate during the adult life of an animal, while cells lateral to it go through continual cell replication. Nevertheless, there is no sufficiently verifiable evidence that the central zone cells contribute to the cells of the region lateral to it. We are pursuing this evidence.