Isoherranen Lab


For full list of the lab’s publications click here.

Retinoic acid and vitamin A related:

Commensals Suppress Intestinal Epithelial Cell Retinoic Acid Synthesis to Regulate Interleukin-22 Activity and Prevent Microbial Dysbiosis. Grizotte-Lake M, Zhong G, Duncan K, Kirkwood J, Iyer N, Smolenski I, Isoherranen N, Vaishnava S. Immunity. 2018 Dec 18;49(6):1103-1115.e6.

CYP26C1 Is a Hydroxylase of Multiple Active Retinoids and Interacts with Cellular Retinoic Acid Binding Proteins. Zhong G, Ortiz D, Zelter A, Nath A, Isoherranen NMol Pharmacol. 2018 May;93(5):489-503.

Inhibition of the all-trans Retinoic Acid (atRA) Hydroxylases CYP26A1 and CYP26B1 Results in Dynamic, Tissue-Specific Changes in Endogenous atRA Signaling. Stevison F, Hogarth C, Tripathy S, Kent T, Isoherranen NDrug Metab Dispos. 2017 Jul;45(7):846-854.

Physiologically Based Pharmacokinetic Model of All-trans-Retinoic Acid with Application to Cancer Populations and Drug Interactions. Jing J, Nelson C, Paik J, Shirasaka Y, Amory JK, Isoherranen NJ Pharmacol Exp Ther. 2017 May;361(2):246-258.

Direct protein-protein interactions and substrate channeling between cellular retinoic acid binding proteins and CYP26B1. Nelson CH, Peng CC, Lutz JD, Yeung CK, Zelter A, Isoherranen NFEBS Lett. 2016 Aug;590(16):2527-35.

Pharmacological inhibition of ALDH1A in mice decreases all-trans retinoic acid concentrations in a tissue specific manner. Arnold SL, Kent T, Hogarth CA, Griswold MD, Amory JK, Isoherranen NBiochem Pharmacol. 2015 Jun 1;95(3):177-92.

Processive pulses of retinoic acid propel asynchronous and continuous murine sperm production. Hogarth CA, Arnold S, Kent T, Mitchell D, Isoherranen N, Griswold MD. Biol Reprod. 2015 Feb;92(2):37.

Drug disposition in specific populations related:

Cannabis use during pregnancy: Pharmacokinetics and effects on child development. Grant KS, Petroff R, Isoherranen N, Stella N, Burbacher TM. Pharmacol Ther. 2018 Feb;182:133-151.

Physiologically Based Pharmacokinetic Model of the CYP2D6 Probe Atomoxetine: Extrapolation to Special Populations and Drug-Drug Interactions. Huang W, Nakano M, Sager J, Ragueneau-Majlessi I, Isoherranen NDrug Metab Dispos. 2017 Nov;45(11):1156-1165.

Chronic Kidney Disease Alters Vitamin A Homeostasis via Effects on Hepatic RBP4 Protein Expression and Metabolic Enzymes. Jing J, Isoherranen N, Robinson-Cohen C, Petrie I, Kestenbaum BR, Yeung CK. Clin Transl Sci. 2016 Aug;9(4):207-15.

Drug metabolism and transport during pregnancy: how does drug disposition change during pregnancy and what are the mechanisms that cause such changes? Isoherranen N, Thummel KE. Drug Metab Dispos. 2013 Feb;41(2):256-62.

Quantitative prediction of CYP2B6 induction by estradiol during pregnancy: potential explanation for increased methadone clearance during pregnancy. Dickmann LJ, Isoherranen N. Drug Metab Dispos. 2013 Feb;41(2):270-4.

In the area of Drug-drug interactions and PBPK modeling:

Does In Vitro Cytochrome P450 Downregulation Translate to In Vivo Drug-Drug Interactions? Preclinical and Clinical Studies With 13-cis-Retinoic Acid.

Stevison F, Kosaka M, Kenny JR, Wong S, Hogarth C, Amory JK, Isoherranen NClin Transl Sci. 2019 Jan 25. doi: 10.1111/cts.12616.

Development of a Dynamic Physiologically Based Mechanistic Kidney Model to Predict Renal Clearance. Huang W, Isoherranen NCPT Pharmacometrics Syst Pharmacol. 2018 Sep;7(9):593-602.

Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model Verification. Sager JE, Yu J, Ragueneau-Majlessi I, Isoherranen NDrug Metab Dispos. 2015 Nov;43(11):1823-37.

Fluoxetine- and norfluoxetine-mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19, and CYP3A4. Sager JE, Lutz JD, Foti RS, Davis C, Kunze KL, Isoherranen NClin Pharmacol Ther. 2014 Jun;95(6):653-62.

Are circulating metabolites important in drug-drug interactions?: Quantitative analysis of risk prediction and inhibitory potency. Yeung CK, Fujioka Y, Hachad H, Levy RH, Isoherranen N. Clin Pharmacol Ther. 2011 Jan;89(1):105-13.